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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1kziTHGThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1kziTHGThymidylate synthase/1.000
1f4fTP3Thymidylate synthase/0.598
1nceCB3Thymidylate synthase/0.580
1fwmCB3Thymidylate synthase/0.576
1aiqCB3Thymidylate synthase/0.573
1kceCB3Thymidylate synthase/0.569
1jtqLY3Thymidylate synthase/0.562
2ftoCB3Thymidylate synthase/0.562
1jtuLYBThymidylate synthase/0.560
2bbqPFGThymidylate synthase/0.557
1dduCB3Thymidylate synthase/0.553
1f4gTP4Thymidylate synthase/0.553
1kzjCB3Thymidylate synthase/0.551
1tysDHFThymidylate synthase/0.548
3bgxMEFThymidylate synthase/0.543
1dnaCB3Thymidylate synthase/0.542
1zprCB3Thymidylate synthase/0.539
2tscCB3Thymidylate synthase/0.539
4fqsLYAThymidylate synthase ThyA/0.539
4knzCB3Thymidylate synthase/0.535
4gevCB3Thymidylate synthase/0.532
1jutLYDThymidylate synthase/0.531
2kceD16Thymidylate synthase/0.530
3bhlTHGThymidylate synthase/0.527
1trgCB3Thymidylate synthase/0.504
1an5CB3Thymidylate synthase/0.493
1tduCB3Thymidylate synthase/0.492
4fogC2FThymidylate synthase ThyA/0.491
3bhrTHGThymidylate synthase/0.490
4ez8DHFThymidylate synthase2.1.1.450.490
1hvyD16Thymidylate synthase2.1.1.450.489
4isk1JYThymidylate synthase/0.489
1bq1CB3Thymidylate synthase/0.488
1axwMTXThymidylate synthase/0.479
2aazCB3Thymidylate synthase2.1.1.450.464
4o7uTHFThymidylate synthase/0.463
3k2hLYABifunctional dihydrofolate reductase-thymidylate synthase/0.462
3uwlFOZThymidylate synthase/0.461
1ju6LYAThymidylate synthase2.1.1.450.457
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.451
2w4qCBWProstaglandin reductase 21.3.1.480.447
4eb4D16Thymidylate synthase2.1.1.450.446
1tsdF89Thymidylate synthase/0.442