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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1jtqLY3Thymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1jtqLY3Thymidylate synthase/1.000
1dnaCB3Thymidylate synthase/0.692
1axwMTXThymidylate synthase/0.668
1fwmCB3Thymidylate synthase/0.625
1nceCB3Thymidylate synthase/0.591
2bbqPFGThymidylate synthase/0.566
1kceCB3Thymidylate synthase/0.559
2ftoCB3Thymidylate synthase/0.556
1aiqCB3Thymidylate synthase/0.553
1tysDHFThymidylate synthase/0.548
1kziTHGThymidylate synthase/0.546
3bgxMEFThymidylate synthase/0.538
4knzCB3Thymidylate synthase/0.534
1trgCB3Thymidylate synthase/0.533
1jtuLYBThymidylate synthase/0.530
1jutLYDThymidylate synthase/0.524
1tduCB3Thymidylate synthase/0.515
4gevCB3Thymidylate synthase/0.515
1kzjCB3Thymidylate synthase/0.514
4fqsLYAThymidylate synthase ThyA/0.514
1zprCB3Thymidylate synthase/0.510
4fogC2FThymidylate synthase ThyA/0.510
1hvyD16Thymidylate synthase2.1.1.450.507
1f4fTP3Thymidylate synthase/0.502
1ju6LYAThymidylate synthase2.1.1.450.502
1dduCB3Thymidylate synthase/0.500
2tscCB3Thymidylate synthase/0.496
1an5CB3Thymidylate synthase/0.490
2aazCB3Thymidylate synthase2.1.1.450.489
3k2hLYABifunctional dihydrofolate reductase-thymidylate synthase/0.485
3bhlTHGThymidylate synthase/0.478
4ez8DHFThymidylate synthase2.1.1.450.477
1f4gTP4Thymidylate synthase/0.475
3uwlFOZThymidylate synthase/0.474
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.470
1jujLYAThymidylate synthase2.1.1.450.468
4foxD16Thymidylate synthase ThyA/0.468
1bq1CB3Thymidylate synthase/0.466
1f28F89Thymidylate synthase2.1.1.450.466
4isk1JYThymidylate synthase/0.466
1tsdF89Thymidylate synthase/0.463
3bhrTHGThymidylate synthase/0.460
2kceD16Thymidylate synthase/0.459
4eb4D16Thymidylate synthase2.1.1.450.449
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443