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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1ipeNDPTropinone reductase 21.1.1.236

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1ipeNDPTropinone reductase 21.1.1.2361.000
1ae1NAPTropinone reductase 1/0.573
4j7uNAPSepiapterin reductase1.1.1.1530.561
4j7xNAPSepiapterin reductase1.1.1.1530.560
1oaaNAPSepiapterin reductase1.1.1.1530.556
4hwkNAPSepiapterin reductase1.1.1.1530.556
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.553
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.551
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.550
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.548
5idwNAPShort-chain dehydrogenase/reductase SDR/0.543
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.541
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.532
1xg5NAPDehydrogenase/reductase SDR family member 11/0.531
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.529
1snyNAPLD36273p/0.525
2bd0NAPSepiapterin reductase/0.519
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.518
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.517
3p19NDPPutative blue fluorescent protein/0.516
4qecNAPElxO/0.513
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.511
3gy0NAPNAD(P)-dependent oxidoreductase/0.510
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.510
3toxNAPPutative oxidoreductase/0.509
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.507
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.504
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.497
2dteNAIGlucose 1-dehydrogenase related protein/0.494
1n5dNDPCarbonyl reductase [NADPH] 1/0.493
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.493
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.491
4bmvNAPShort-chain dehydrogenase/0.491
1w4zNAPPutative ketoacyl reductase1.3.10.490
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.489
3l77NJPShort-chain alcohol dehydrogenase/0.489
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.488
2yutNAPPutative short-chain oxidoreductase/0.487
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.486
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.485
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.484
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.483
3d3wNAPL-xylulose reductase1.1.1.100.483
4dc1NDPPutative ketoacyl reductase1.3.10.481
1x7hNDPPutative ketoacyl reductase1.3.10.480
1x7gNAPPutative ketoacyl reductase1.3.10.479
2jahNDPClavaldehyde dehydrogenase/0.479
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
1pr9NAPL-xylulose reductase1.1.1.100.476
3qrwNDPPutative ketoacyl reductase1.3.10.476
4qedNAPElxO/0.475
1wntNAPL-xylulose reductase1.1.1.100.474
4fn4NADShort chain dehydrogenase/0.474
1rwbNADGlucose 1-dehydrogenase1.1.1.470.472
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.471
1xkqNDPUncharacterized protein/0.471
3sjuNDPKeto reductase/0.471
4esoNAPPutative oxidoreductase/0.471
3tn7NJPShort-chain alcohol dehydrogenase/0.470
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.470
5jlaNADPutative short-chain dehydrogenase/reductase/0.470
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.469
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.468
2gn8NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting)4.2.1.1150.467
3ai3NDPNADPH-sorbose reductase/0.465
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.463
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.462
3lqfNADGalactitol dehydrogenase/0.462
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.458
3w8eNAD3-hydroxybutyrate dehydrogenase/0.457
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.455
4yagNAIC alpha-dehydrogenase/0.454
3f1kNAPUncharacterized oxidoreductase YciK10.452
4yaiNAIC alpha-dehydrogenase/0.452
3ak4NADNADH-dependent quinuclidinone reductase/0.448
2wdzNADGalactitol dehydrogenase/0.447
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.446
3u4cNDPNADPH-dependent reductase BacG/0.446
3vdqNAD3-hydroxybutyrate dehydrogenase/0.446
1gcoNADGlucose 1-dehydrogenase1.1.1.470.445
2yy7NADL-threonine dehydrogenase/0.445
4gh5NADShort-chain dehydrogenase/reductase SDR/0.445
1g6kNADGlucose 1-dehydrogenase1.1.1.470.444
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.443
3s55NADPutative short-chain dehydrogenase/reductase/0.442
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.442
1geeNADGlucose 1-dehydrogenase1.1.1.470.441
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.441
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.440
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.440
3ai2NDPNADPH-sorbose reductase/0.440