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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1grgFADGlutathione reductase, mitochondrial1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1grgFADGlutathione reductase, mitochondrial1.8.1.71.000
1grhFADGlutathione reductase, mitochondrial1.8.1.70.955
1greFADGlutathione reductase, mitochondrial1.8.1.70.908
3grsFADGlutathione reductase, mitochondrial1.8.1.70.848
1graFADGlutathione reductase, mitochondrial1.8.1.70.835
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.820
1grbFADGlutathione reductase, mitochondrial1.8.1.70.707
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.632
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.622
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.595
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.590
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.580
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.579
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.555
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.542
2v6oFADThioredoxin glutathione reductase/0.527
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.514
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.472
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.467
2r9zFADGlutathione amide reductase/0.466
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.464
1gerFADGlutathione reductase1.8.1.70.462
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.462
2rabFADGlutathione amide reductase/0.458
3djgFADGlutathione reductase, mitochondrial1.8.1.70.456
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.451
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.447