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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1graFADGlutathione reductase, mitochondrial1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1graFADGlutathione reductase, mitochondrial1.8.1.71.000
1greFADGlutathione reductase, mitochondrial1.8.1.70.885
1grhFADGlutathione reductase, mitochondrial1.8.1.70.871
1grgFADGlutathione reductase, mitochondrial1.8.1.70.868
3grsFADGlutathione reductase, mitochondrial1.8.1.70.860
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.860
1grbFADGlutathione reductase, mitochondrial1.8.1.70.706
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.633
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.626
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.617
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.609
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.607
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.604
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.575
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.544
2v6oFADThioredoxin glutathione reductase/0.538
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.504
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.477
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.474
2r9zFADGlutathione amide reductase/0.473
2rabFADGlutathione amide reductase/0.473
3djgFADGlutathione reductase, mitochondrial1.8.1.70.463
1gerFADGlutathione reductase1.8.1.70.454
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.452
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.446
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.446
1geuFADGlutathione reductase1.8.1.70.441