sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1got | GDP | Guanine nucleotide-binding protein G(t) subunit alpha-1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1got | GDP | Guanine nucleotide-binding protein G(t) subunit alpha-1 | / | 1.000 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.516 | |
| 1y3a | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.503 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.501 | |
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.500 | |
| 3c16 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.494 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.485 | |
| 1cul | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.477 | |
| 3c15 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.476 | |
| 3c14 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.475 | |
| 2gvd | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.474 | |
| 1edo | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic | 1.1.1.100 | 0.473 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.467 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.465 | |
| 1azt | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.464 | |
| 1cs4 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.459 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.459 | |
| 5iqi | GNP | Bifunctional AAC/APH | 2.3.1 | 0.459 | |
| 1u0h | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.458 | |
| 4e07 | ACP | Plasmid partitioning protein ParF | / | 0.458 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.458 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.457 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.456 | |
| 1fdu | NAP | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 2cdu | FAD | NADH oxidase | / | 0.454 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.454 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.453 | |
| 2eba | FAD | Putative glutaryl-CoA dehydrogenase | / | 0.453 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.452 | |
| 2ign | FAD | Pyranose 2-oxidase | / | 0.452 | |
| 1h6d | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.451 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.451 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.450 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.449 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.449 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.449 | |
| 3uoy | NAP | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.448 | |
| 3tz3 | B36 | Acetyl-CoA carboxylase | / | 0.447 | |
| 5kje | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 1gp2 | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.446 | |
| 4ctk | SAM | Genome polyprotein | / | 0.446 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.445 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.445 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.444 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.444 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.444 | |
| 4dwv | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.444 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.444 | |
| 1lde | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1rx0 | FAD | Isobutyryl-CoA dehydrogenase, mitochondrial | 1.3.99 | 0.443 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.443 | |
| 3qwf | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.443 | |
| 4kqw | NAP | Ketol-acid reductoisomerase (NADP(+)) | / | 0.443 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1ht0 | NAD | Alcohol dehydrogenase 1C | 1.1.1.1 | 0.442 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.442 | |
| 4fj2 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.442 | |
| 1qf5 | RPL | Adenylosuccinate synthetase | / | 0.441 | |
| 1v0j | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.441 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.441 | |
| 3kyb | FAD | UDP-galactopyranose mutase | 5.4.99.9 | 0.441 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.441 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.441 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.441 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.440 | |
| 1w5s | ADP | ORC1-type DNA replication protein 2 | / | 0.440 | |
| 2c0c | NAP | Prostaglandin reductase 3 | 1 | 0.440 | |
| 2ql6 | ADP | Nicotinamide riboside kinase 1 | / | 0.440 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.440 |