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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1gesFADGlutathione reductase1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1gesFADGlutathione reductase1.8.1.71.000
1geuFADGlutathione reductase1.8.1.70.624
1gerFADGlutathione reductase1.8.1.70.604
1getFADGlutathione reductase1.8.1.70.587
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.535
2rabFADGlutathione amide reductase/0.508
2zz0FADThioredoxin reductase 1, cytoplasmic1.8.1.90.491
1zmdFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.484
3cgeFADCoenzyme A disulfide reductase/0.476
3lqfNADGalactitol dehydrogenase/0.471
3ic9FADPutative dihydrolipoamide dehydrogenase/0.470
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.468
3djjFADGlutathione reductase, mitochondrial1.8.1.70.465
1grbFADGlutathione reductase, mitochondrial1.8.1.70.460
2bryFAD[F-actin]-methionine sulfoxide oxidase MICAL11.14.130.459
1djnADPTrimethylamine dehydrogenase1.5.8.20.452
3s5wFADL-ornithine N(5)-monooxygenase/0.451
2eq7FADDihydrolipoyl dehydrogenase/0.449
5jlaNADPutative short-chain dehydrogenase/reductase/0.449
2npxFADNADH peroxidase1.11.1.10.447
4tm4FDAKtzI/0.447
1f8wFADNADH peroxidase1.11.1.10.446
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.446
3l8kADPDihydrolipoamide dehydrogenase (PdhD-3)/0.445
4b69FADL-ornithine N(5)-monooxygenase/0.444
1djqADPTrimethylamine dehydrogenase1.5.8.20.441
5jydNADShort chain dehydrogenase/0.440