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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1geeNADGlucose 1-dehydrogenase1.1.1.47

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1geeNADGlucose 1-dehydrogenase1.1.1.471.000
1gcoNADGlucose 1-dehydrogenase1.1.1.470.861
1g6kNADGlucose 1-dehydrogenase1.1.1.470.575
1rwbNADGlucose 1-dehydrogenase1.1.1.470.575
3toxNAPPutative oxidoreductase/0.528
4j7uNAPSepiapterin reductase1.1.1.1530.519
3p19NDPPutative blue fluorescent protein/0.514
4j7xNAPSepiapterin reductase1.1.1.1530.506
1x7gNAPPutative ketoacyl reductase1.3.10.505
3w8eNAD3-hydroxybutyrate dehydrogenase/0.505
4hwkNAPSepiapterin reductase1.1.1.1530.500
1w4zNAPPutative ketoacyl reductase1.3.10.499
1x7hNDPPutative ketoacyl reductase1.3.10.498
2wdzNADGalactitol dehydrogenase/0.489
3ai2NDPNADPH-sorbose reductase/0.489
3vdqNAD3-hydroxybutyrate dehydrogenase/0.489
5jlaNADPutative short-chain dehydrogenase/reductase/0.489
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.486
1ipeNDPTropinone reductase 21.1.1.2360.485
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.484
1wntNAPL-xylulose reductase1.1.1.100.483
3l77NJPShort-chain alcohol dehydrogenase/0.482
4b79NADProbable short-chain dehydrogenase/0.481
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.481
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.480
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.479
1pr9NAPL-xylulose reductase1.1.1.100.478
4dc1NDPPutative ketoacyl reductase1.3.10.478
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.478
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.478
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.475
3bmoNAPPteridine reductase/0.475
3qrwNDPPutative ketoacyl reductase1.3.10.475
1xg5NAPDehydrogenase/reductase SDR family member 11/0.472
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.472
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.470
5idwNAPShort-chain dehydrogenase/reductase SDR/0.470
1ae1NAPTropinone reductase 1/0.467
3gy0NAPNAD(P)-dependent oxidoreductase/0.467
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.466
2dteNAIGlucose 1-dehydrogenase related protein/0.466
4bmvNAPShort-chain dehydrogenase/0.466
4gh5NADShort-chain dehydrogenase/reductase SDR/0.466
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.464
2wsbNADGalactitol dehydrogenase/0.464
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.464
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.463
1xkqNDPUncharacterized protein/0.463
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.463
2yutNAPPutative short-chain oxidoreductase/0.463
3wdsNADNADH-dependent quinuclidinone reductase/0.463
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.463
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.462
1oaaNAPSepiapterin reductase1.1.1.1530.462
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.462
2bd0NAPSepiapterin reductase/0.460
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.460
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.460
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.460
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.459
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.459
1snyNAPLD36273p/0.458
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
4yagNAIC alpha-dehydrogenase/0.458
4yaiNAIC alpha-dehydrogenase/0.458
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.457
3d3wNAPL-xylulose reductase1.1.1.100.457
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.455
1iy8NADLevodione reductase/0.454
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.454
2jahNDPClavaldehyde dehydrogenase/0.454
3lqfNADGalactitol dehydrogenase/0.454
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.454
3w8fNAD3-hydroxybutyrate dehydrogenase/0.454
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.454
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.452
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
4fn4NADShort chain dehydrogenase/0.452
4qecNAPElxO/0.452
3sjuNDPKeto reductase/0.451
1n5dNDPCarbonyl reductase [NADPH] 1/0.450
1qyvNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.450
3f1kNAPUncharacterized oxidoreductase YciK10.450
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.449
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.446
3ak4NADNADH-dependent quinuclidinone reductase/0.446
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.446
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.446
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.444
3tn7NJPShort-chain alcohol dehydrogenase/0.444
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
3w8dNAD3-hydroxybutyrate dehydrogenase/0.443
4esoNAPPutative oxidoreductase/0.443
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.442
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.442
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.441
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.441
5dp2NAPCurF/0.441
4q71FADBifunctional protein PutA/0.440