sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1fxf | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 1.000 | |
| 1fx9 | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.681 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.569 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.483 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.465 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.461 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.459 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.457 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.455 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.454 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.453 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.452 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.452 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.452 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.452 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.452 | |
| 4okx | 198 | Androgen receptor | / | 0.451 | |
| 4ruo | BIV | Vitamin D3 receptor A | / | 0.451 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 1eio | GCH | Gastrotropin | / | 0.448 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4b65 | FAD | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 3slk | NDP | Polyketide synthase extender module 2 | / | 0.446 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.445 | |
| 3owa | FAD | Acyl-CoA dehydrogenase | / | 0.445 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.445 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.445 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.444 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 2ejz | SAH | Diphthine synthase | / | 0.443 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.443 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.442 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.441 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.441 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.441 | |
| 2v5a | LZL | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.440 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.440 | |
| 4j53 | 1J4 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.440 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 |