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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1eqhFLPProstaglandin G/H synthase 11.14.99.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1eqhFLPProstaglandin G/H synthase 11.14.99.11.000
1eqgIBPProstaglandin G/H synthase 11.14.99.10.790
1ht834CProstaglandin G/H synthase 11.14.99.10.654
4fm5DF0Prostaglandin G/H synthase 21.14.99.10.647
1q4gBFLProstaglandin G/H synthase 11.14.99.10.643
2aylFLPProstaglandin G/H synthase 11.14.99.10.613
2oyeIM8Prostaglandin G/H synthase 11.14.99.10.613
3n8wFLPProstaglandin G/H synthase 11.14.99.10.608
3n8zFLPProstaglandin G/H synthase 11.14.99.10.590
3ntgD72Prostaglandin G/H synthase 21.14.99.10.587
3rr3FLRProstaglandin G/H synthase 21.14.99.10.587
3n8xNIMProstaglandin G/H synthase 11.14.99.10.579
4coxIMNProstaglandin G/H synthase 21.14.99.10.576
3pghFLPProstaglandin G/H synthase 21.14.99.10.572
4ph9IBPProstaglandin G/H synthase 21.14.99.10.564
3q7dNPXProstaglandin G/H synthase 21.14.99.10.563
3ln1CELProstaglandin G/H synthase 21.14.99.10.557
2oyuIMSProstaglandin G/H synthase 11.14.99.10.550
3mqe416Prostaglandin G/H synthase 21.14.99.10.525
5ikrID8Prostaglandin G/H synthase 21.14.99.10.522
4otyLURProstaglandin G/H synthase 21.14.99.10.499
4rrwLURProstaglandin G/H synthase 21.14.99.10.492
4rrzLURProstaglandin G/H synthase 21.14.99.10.492
4rrxLURProstaglandin G/H synthase 21.14.99.10.490
5ikqJMSProstaglandin G/H synthase 21.14.99.10.484
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.482
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.482
3kk6CELProstaglandin G/H synthase 11.14.99.10.480
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.473
2hcdBIVVitamin D3 receptor A/0.472
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.465
3vf60H6Glucokinase2.7.1.20.465
1qlhNADAlcohol dehydrogenase E chain1.1.1.10.462
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
3nwq2NCGag-Pol polyprotein3.4.23.160.458
3n8yDIFProstaglandin G/H synthase 11.14.99.10.457
3ln052BProstaglandin G/H synthase 21.14.99.10.456
1cbrREACellular retinoic acid-binding protein 1/0.455
2ca0PXICytochrome P450 monooxygenase PikC/0.455
2qg2A91Heat shock protein HSP 90-alpha/0.455
4nr42LKCREB-binding protein/0.455
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.454
4eb4D16Thymidylate synthase2.1.1.450.454
4y8wSTRSteroid 21-hydroxylase/0.454
2om9AJAPeroxisome proliferator-activated receptor gamma/0.453
4a2aATPCell division protein FtsA/0.453
5uviZMAAdenosine receptor A2a/0.453
3pqbVGPPutative oxidoreductase/0.452
4kwi1TJReductase homolog/0.452
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.451
1efvFADElectron transfer flavoprotein subunit alpha, mitochondrial/0.450
3vspEK8Peroxisome proliferator-activated receptor gamma/0.450
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.450
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.450
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.450
1p0hACOMycothiol acetyltransferase2.3.1.1890.449
2q5g1FAPeroxisome proliferator-activated receptor delta/0.449
3mnrSD1Heat shock protein HSP 90-alpha/0.449
4djaFAD(6-4) photolyase/0.449
4u9yCOAAlpha-tubulin N-acetyltransferase 1/0.449
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.448
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
3dds26BGlycogen phosphorylase, liver form2.4.1.10.447
3f63GTXGlutathione transferase GST1-4/0.447
1xddAAYIntegrin alpha-L/0.446
3mdvCL6Cholesterol 24-hydroxylase/0.446
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3vqsJT1Genome polyprotein/0.446
1fm4DXCMajor pollen allergen Bet v 1-L/0.445
3cwkREACellular retinoic acid-binding protein 2/0.445
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
4iae1DXAlr2278 protein/0.444
1wlvCOAPhenylacetic acid degradation protein PaaI/0.443
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
3el4ROCGag-Pol polyprotein3.4.23.160.443
3v9v21LPeroxisome proliferator-activated receptor gamma/0.443
5jlaNADPutative short-chain dehydrogenase/reductase/0.443
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1ryeNDPGlucose--fructose oxidoreductase1.1.99.280.442
4jqh1MFAlr2278 protein/0.442
1a72PADAlcohol dehydrogenase E chain1.1.1.10.441
1tduCB3Thymidylate synthase/0.441
3d7kD7KBenzaldehyde lyase/0.441
3w2wATPCRISPR system Cmr subunit Cmr2/0.441
4xldBRLPeroxisome proliferator-activated receptor gamma/0.441
1k7l544Peroxisome proliferator-activated receptor alpha/0.440
1uyePU9Heat shock protein HSP 90-alpha/0.440
1ysx4EBSerum albumin/0.440
1zdwFLVPrenyltransferase/0.440
2fwyH64Heat shock protein HSP 90-alpha/0.440
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.440
2oxtSAMGenome polyprotein/0.440
2y60M8FIsopenicillin N synthase1.21.3.10.440
3hk1B64Fatty acid-binding protein, adipocyte/0.440
3nx4NAPPutative oxidoreductase/0.440
4bb3KKAIsopenicillin N synthase1.21.3.10.440
4e4qRRHPeroxisome proliferator-activated receptor gamma/0.440
4eajATP5'-AMP-activated protein kinase subunit gamma-1/0.440
4iah1DXAlr2278 protein/0.440
4q72FADBifunctional protein PutA/0.440