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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1dduDDUThymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1dduDDUThymidylate synthase/1.000
1dduCB3Thymidylate synthase/0.879
1tduDURThymidylate synthase/0.644
1fwmCB3Thymidylate synthase/0.593
1tduCB3Thymidylate synthase/0.551
3bgxTMPThymidylate synthase/0.545
1an5CB3Thymidylate synthase/0.540
2vetUMPThymidylate synthase/0.538
4iskUMPThymidylate synthase/0.536
1bduDURThymidylate synthase/0.535
1aobDDUThymidylate synthase/0.534
1bidUMPThymidylate synthase/0.527
4xsdUMPThymidylate synthase2.1.1.450.523
4einNOHThymidylate synthase2.1.1.450.522
3bgxMEFThymidylate synthase/0.520
1njaDCMThymidylate synthase/0.519
4dq1UMPThymidylate synthase/0.516
2ftoTMPThymidylate synthase/0.511
3dgaUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.509
1tsyUMPThymidylate synthase/0.505
4eb4UMPThymidylate synthase2.1.1.450.504
1f4gTP4Thymidylate synthase/0.503
1tysTMPThymidylate synthase/0.503
1jmgUMPThymidylate synthase/0.502
3bhlTHGThymidylate synthase/0.502
1njbUMPThymidylate synthase/0.500
4gevCB3Thymidylate synthase/0.499
4foxUMPThymidylate synthase ThyA/0.495
4h0uUMPThymidylate synthase/0.493
4e5oUMPThymidylate synthase2.1.1.450.490
4o7uTHFThymidylate synthase/0.490
4fogC2FThymidylate synthase ThyA/0.489
1njdUMPThymidylate synthase/0.487
5by6UMPThymidylate synthase/0.486
1njcDCMThymidylate synthase/0.485
2g89UMPThymidylate synthase/0.485
1f28UMPThymidylate synthase2.1.1.450.484
1ci7UMPThymidylate synthase2.1.1.450.483
1thyUMPThymidylate synthase/0.483
1tsxUMPThymidylate synthase/0.483
2g86UMPThymidylate synthase/0.483
2tsrUMPThymidylate synthase2.1.1.450.480
2g8aUMPThymidylate synthase/0.478
4lrrCF9Thymidylate synthase/0.478
3qj7UMPThymidylate synthase ThyA/0.477
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.477
4knzCB3Thymidylate synthase/0.475
1jmiUMPThymidylate synthase/0.473
3dg8UMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.473
1jmhUMPThymidylate synthase/0.471
1b5eDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.469
1vzaUMPThymidylate synthase/0.468
1bp6UMPThymidylate synthase/0.467
4psgNOHThymidylate synthase/0.467
4irrUMPThymidylate synthase/0.466
4dpdUMPBifunctional dihydrofolate reductase-thymidylate synthase/0.464
1vzbUMPThymidylate synthase/0.458
1njeDCMThymidylate synthase/0.453
1jmfUMPThymidylate synthase/0.452
2gesCOKPantothenate kinase2.7.1.330.452
1tsvUMPThymidylate synthase/0.450
1b5dDCMDeoxycytidylate 5-hydroxymethyltransferase2.1.2.80.448
1lcbTMPThymidylate synthase/0.443
1obnASVIsopenicillin N synthase1.21.3.10.442