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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1bwcFADGlutathione reductase, mitochondrial1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1bwcFADGlutathione reductase, mitochondrial1.8.1.71.000
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.625
1grhFADGlutathione reductase, mitochondrial1.8.1.70.608
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.608
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.605
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.599
1greFADGlutathione reductase, mitochondrial1.8.1.70.598
1grgFADGlutathione reductase, mitochondrial1.8.1.70.597
3grsFADGlutathione reductase, mitochondrial1.8.1.70.595
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.593
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.588
1graFADGlutathione reductase, mitochondrial1.8.1.70.571
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.548
1grbFADGlutathione reductase, mitochondrial1.8.1.70.547
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.529
2v6oFADThioredoxin glutathione reductase/0.502
2r9zFADGlutathione amide reductase/0.490
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.482
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.477
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.471
3djgFADGlutathione reductase, mitochondrial1.8.1.70.462
1gerFADGlutathione reductase1.8.1.70.461
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.454
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.447
1zx9FADMercuric reductase1.16.1.10.440
2rabFADGlutathione amide reductase/0.440