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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1az2NAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1az2NAPAldose reductase1.1.1.211.000
2iq0NAPAldose reductase1.1.1.210.775
1x96NAPAldose reductase1.1.1.210.695
2acsNAPAldose reductase1.1.1.210.671
2acuNAPAldose reductase1.1.1.210.634
1x98NAPAldose reductase1.1.1.210.631
2acqNAPAldose reductase1.1.1.210.625
2pevNDPAldose reductase1.1.1.210.612
2pf8NDPAldose reductase1.1.1.210.611
2j8tNAPAldose reductase1.1.1.210.604
2pfhNDPAldose reductase1.1.1.210.589
3q67NAPAldose reductase1.1.1.210.589
1ah4NAPAldose reductase1.1.1.210.575
3q65NAPAldose reductase1.1.1.210.560
3v36NAPAldose reductase1.1.1.210.551
1adsNAPAldose reductase1.1.1.210.545
4g5dNDPProstaglandin F synthase1.1.1.1880.545
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.544
3h7rNAPAldo-keto reductase family 4 member C8/0.541
1z8aNAPAldose reductase1.1.1.210.536
3qkzNAPAldose reductase-related protein 11.1.1.210.533
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.531
4pmjNAPPutative oxidoreductase/0.527
2hejNDPAldo-keto reductase family 1 member C211.1.10.524
3o3rNAPAldose reductase-related protein 11.1.1.210.511
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.508
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.508
1c9wNAPAldose reductase-related protein 2/0.504
4xo7NAPAldo-keto reductase family 1 member C2/0.495
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.491
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.491
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.487
3wczNAPAldo-keto reductase AKR2E4/0.487
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.480
1zgdNAPChalcone reductase/0.480
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.477
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.476
1vp5NAPOxidoreductase, aldo/keto reductase family/0.473
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.469
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.465
4jtqNAPAldo-keto reductase family 1 member C2/0.464
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.462
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.461
2p5nNDPAldo-keto reductase family 1 member C211.1.10.460
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.460
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.459
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.459
1lqaNDPProtein tas/0.458
1pz1NAPGeneral stress protein 69/0.457
4l1xNAPAldo-keto reductase family 1 member C2/0.456
2r9rNAPVoltage-gated potassium channel subunit beta-2/0.455
1s1rNAPAldo-keto reductase family 1 member C3/0.454
2hdjNDPAldo-keto reductase family 1 member C2/0.454
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.448
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.448
4dz5NAPAldo-keto reductase family 1 member C3/0.446
5c7hNDPPutative oxidoreductase/0.443