sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 1.000 | |
| 1akb | PPD | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.644 | |
| 1maq | PGU | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.627 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.595 | |
| 1ivr | CBA | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.588 | |
| 1map | KET | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.579 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.566 | |
| 3qpg | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.566 | |
| 1cq6 | PY4 | Aspartate aminotransferase | 2.6.1.1 | 0.541 | |
| 1cq8 | PY6 | Aspartate aminotransferase | 2.6.1.1 | 0.539 | |
| 1cq7 | PY5 | Aspartate aminotransferase | 2.6.1.1 | 0.525 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.525 | |
| 1ahg | TYR_PLP | Aspartate aminotransferase | 2.6.1.1 | 0.492 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.461 | |
| 1x28 | PGU | Aspartate aminotransferase | 2.6.1.1 | 0.461 | |
| 1asc | NPL | Aspartate aminotransferase | 2.6.1.1 | 0.459 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.453 | |
| 4g09 | 0VD | Histidinol dehydrogenase | / | 0.453 | |
| 1arg | PPD | Aspartate aminotransferase | 2.6.1.1 | 0.452 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.451 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.447 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.443 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.442 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.442 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.442 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.441 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.441 |