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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hi6 MTX Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5hi6 MTXDihydrofolate reductase / 1.110
2drc MTXDihydrofolate reductase 1.5.1.3 1.003
3och 2MXDihydrofolate reductase 1.5.1.3 0.988
3drc MTXDihydrofolate reductase 1.5.1.3 0.986
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.920
1dra MTXDihydrofolate reductase 1.5.1.3 0.917
3dau MTXDihydrofolate reductase 1.5.1.3 0.913
4p66 MTXDihydrofolate reductase / 0.903
3ia4 MTXDihydrofolate reductase / 0.899
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.891
4qi9 MTXDihydrofolate reductase / 0.882
1df7 MTXDihydrofolate reductase 1.5.1.3 0.875
1dhj MTXDihydrofolate reductase 1.5.1.3 0.874
3tq9 MTXDihydrofolate reductase / 0.871
1drb MTXDihydrofolate reductase 1.5.1.3 0.866
1tdr MTXDihydrofolate reductase 1.5.1.3 0.865
2qk8 MTXDihydrofolate reductase / 0.859
1dls MTXDihydrofolate reductase 1.5.1.3 0.854
3eig MTXDihydrofolate reductase 1.5.1.3 0.852
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.847
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.845
1dre MTXDihydrofolate reductase 1.5.1.3 0.844
1dhi MTXDihydrofolate reductase 1.5.1.3 0.828
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.825
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.825
3dfr MTXDihydrofolate reductase 1.5.1.3 0.824
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.823
4dfr MTXDihydrofolate reductase 1.5.1.3 0.813
4x5f FOLDihydrofolate reductase 1.5.1.3 0.806
1dyh DZFDihydrofolate reductase 1.5.1.3 0.804
3dat MTXDihydrofolate reductase / 0.800
1u70 MTXDihydrofolate reductase 1.5.1.3 0.799
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.796
1jol FFODihydrofolate reductase 1.5.1.3 0.795
1dyj DDFDihydrofolate reductase 1.5.1.3 0.790
4i1n FOLDihydrofolate reductase 1.5.1.3 0.781
3frd DHFDihydrofolate reductase 1.5.1.3 0.780
4i13 FOLDihydrofolate reductase 1.5.1.3 0.778
1e26 GPBDihydrofolate reductase 1.5.1.3 0.777
1hfq MOTDihydrofolate reductase 1.5.1.3 0.769
5ccc DDFDihydrofolate reductase 1.5.1.3 0.768
1u72 MTXDihydrofolate reductase 1.5.1.3 0.767
4x5i FOLDihydrofolate reductase 1.5.1.3 0.765
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.763
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.760
1dyi FOLDihydrofolate reductase 1.5.1.3 0.760
1ohj COPDihydrofolate reductase 1.5.1.3 0.760
1hfp MOTDihydrofolate reductase 1.5.1.3 0.758
2zza FOLDihydrofolate reductase / 0.758
4p68 MTXDihydrofolate reductase / 0.754
4keb FOLDihydrofolate reductase 1.5.1.3 0.753
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.753
1dds MTXDihydrofolate reductase 1.5.1.3 0.752
4x5h FOLDihydrofolate reductase 1.5.1.3 0.751
1jom FFODihydrofolate reductase 1.5.1.3 0.749
1ddr MTXDihydrofolate reductase 1.5.1.3 0.745
1hfr MOTDihydrofolate reductase 1.5.1.3 0.745
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.744
4kjj FOLDihydrofolate reductase 1.5.1.3 0.743
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.742
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.742
4m6k FOLDihydrofolate reductase 1.5.1.3 0.739
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.738
2d0k FOLDihydrofolate reductase 1.5.1.3 0.736
1ohk COPDihydrofolate reductase 1.5.1.3 0.734
2w3m FOLDihydrofolate reductase 1.5.1.3 0.734
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.732
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.731
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.719
3tqb FOLDihydrofolate reductase / 0.719
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.709
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.708
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.707
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.706
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.705
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.703
3ghv GHCDihydrofolate reductase 1.5.1.3 0.700
1re7 FOLDihydrofolate reductase 1.5.1.3 0.696
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.696
1dhf FOLDihydrofolate reductase 1.5.1.3 0.690
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.690
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.689
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.686
4m6l 21VDihydrofolate reductase 1.5.1.3 0.686
4kfj FOLDihydrofolate reductase 1.5.1.3 0.683
1drf FOLDihydrofolate reductase 1.5.1.3 0.680
3ghw GHWDihydrofolate reductase 1.5.1.3 0.680
3td8 D2RDihydrofolate reductase 1.5.1.3 0.679
4x5g FOLDihydrofolate reductase 1.5.1.3 0.677
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.676
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.673
7dfr FOLDihydrofolate reductase 1.5.1.3 0.669
4fhb FOLDihydrofolate reductase 1.5.1.3 0.666
1daj MOTDihydrofolate reductase 1.5.1.3 0.664
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.659
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.658
1hbm SHTMethyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.656
1hbm SHTMethyl-coenzyme M reductase I subunit beta 2.8.4.1 0.656
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.656
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.655
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.654
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.652