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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5hbr COA Acyl-CoA synthetase (NDP forming)

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5hbr COAAcyl-CoA synthetase (NDP forming) / 1.099
4xyl COAAcyl-CoA synthetase (NDP forming) / 0.959
4yak ACOAcyl-CoA synthetase (NDP forming) / 0.842
4xz3 COAAcyl-CoA synthetase (NDP forming) / 0.789
4xym COAAcyl-CoA synthetase (NDP forming) / 0.779
4yak COAAcyl-CoA synthetase (NDP forming) / 0.747
2nua COASuccinate--CoA ligase [ADP-forming] subunit alpha 6.2.1.5 0.724
2nu9 COASuccinate--CoA ligase [ADP-forming] subunit alpha 6.2.1.5 0.698
5cae COASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial 6.2.1.4 0.657
4xx0 COASuccinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial 6.2.1.4 0.655