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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5fuv THM Thymidine kinase, putative

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5fuv THMThymidine kinase, putative / 1.039
5fuw THMThymidine kinase, putative / 0.967
1xbt TTPThymidine kinase, cytosolic 2.7.1.21 0.843
2wvj TTPThymidine kinase, cytosolic 2.7.1.21 0.839
2b8t THMThymidine kinase / 0.787
2uz3 TTPThymidine kinase / 0.786
1zm7 TTPDeoxynucleoside kinase / 0.708
2jcs TTPDeoxynucleoside kinase / 0.704
2vp0 TTPDeoxynucleoside kinase / 0.700
1fxo TMPGlucose-1-phosphate thymidylyltransferase / 0.695
1g0r THMGlucose-1-phosphate thymidylyltransferase / 0.688
1jtk THUCytidine deaminase 3.5.4.5 0.685
1xje TTPVitamin B12-dependent ribonucleotide reductase / 0.683
1p72 THMThymidine kinase / 0.669
1i3l GDUUDP-glucose 4-epimerase / 0.667
4ho4 THMGlucose-1-phosphate thymidylyltransferase / 0.667
4ho8 THMGlucose-1-phosphate thymidylyltransferase / 0.666
3ryk TYDdTDP-4-dehydrorhamnose 3,5-epimerase / 0.661
1i3n UD1UDP-glucose 4-epimerase / 0.660
1w2g THMThymidylate kinase 2.7.4.9 0.658
3enk UPGUDP-glucose 4-epimerase / 0.657
1ot3 THMDeoxynucleoside kinase / 0.656
1i3k UPGUDP-glucose 4-epimerase / 0.650