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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5ccc DDF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5ccc DDFDihydrofolate reductase 1.5.1.3 1.076
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.908
1dyj DDFDihydrofolate reductase 1.5.1.3 0.869
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.868
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.866
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.850
4x5f FOLDihydrofolate reductase 1.5.1.3 0.844
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.842
1dyh DZFDihydrofolate reductase 1.5.1.3 0.818
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.817
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.816
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.795
4x5g FOLDihydrofolate reductase 1.5.1.3 0.794
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.792
4i13 FOLDihydrofolate reductase 1.5.1.3 0.791
1dyi FOLDihydrofolate reductase 1.5.1.3 0.786
1jol FFODihydrofolate reductase 1.5.1.3 0.786
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.783
4kjj FOLDihydrofolate reductase 1.5.1.3 0.777
1jom FFODihydrofolate reductase 1.5.1.3 0.775
7dfr FOLDihydrofolate reductase 1.5.1.3 0.772
5hi6 MTXDihydrofolate reductase / 0.768
2d0k FOLDihydrofolate reductase 1.5.1.3 0.764
4i1n FOLDihydrofolate reductase 1.5.1.3 0.764
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.761
4m6k FOLDihydrofolate reductase 1.5.1.3 0.760
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.759
1dhi MTXDihydrofolate reductase 1.5.1.3 0.758
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.756
3och 2MXDihydrofolate reductase 1.5.1.3 0.756
1hfq MOTDihydrofolate reductase 1.5.1.3 0.752
3drc MTXDihydrofolate reductase 1.5.1.3 0.751
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.750
1drb MTXDihydrofolate reductase 1.5.1.3 0.747
1hfr MOTDihydrofolate reductase 1.5.1.3 0.747
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.743
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.743
2drc MTXDihydrofolate reductase 1.5.1.3 0.740
4fhb FOLDihydrofolate reductase 1.5.1.3 0.737
3frd DHFDihydrofolate reductase 1.5.1.3 0.734
1tdr MTXDihydrofolate reductase 1.5.1.3 0.732
3tqb FOLDihydrofolate reductase / 0.732
1dhj MTXDihydrofolate reductase 1.5.1.3 0.731
3dau MTXDihydrofolate reductase 1.5.1.3 0.728
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.728
4dfr MTXDihydrofolate reductase 1.5.1.3 0.726
3tq9 MTXDihydrofolate reductase / 0.725
4kfj FOLDihydrofolate reductase 1.5.1.3 0.725
1dra MTXDihydrofolate reductase 1.5.1.3 0.724
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.724
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.722
3ghv GHCDihydrofolate reductase 1.5.1.3 0.720
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.719
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.719
1dre MTXDihydrofolate reductase 1.5.1.3 0.718
3eig MTXDihydrofolate reductase 1.5.1.3 0.714
1hfp MOTDihydrofolate reductase 1.5.1.3 0.713
4p66 MTXDihydrofolate reductase / 0.712
2qk8 MTXDihydrofolate reductase / 0.711
1ohj COPDihydrofolate reductase 1.5.1.3 0.708
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.707
1dhf FOLDihydrofolate reductase 1.5.1.3 0.705
4x5h FOLDihydrofolate reductase 1.5.1.3 0.703
1df7 MTXDihydrofolate reductase 1.5.1.3 0.701
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.701
1re7 FOLDihydrofolate reductase 1.5.1.3 0.698
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.697
4p68 MTXDihydrofolate reductase / 0.697
4qi9 MTXDihydrofolate reductase / 0.696
3ia4 MTXDihydrofolate reductase / 0.694
2zza FOLDihydrofolate reductase / 0.692
4m6l 21VDihydrofolate reductase 1.5.1.3 0.691
1u72 MTXDihydrofolate reductase 1.5.1.3 0.689
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.686
1hbn TP7Methyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.684
1hbn TP7Methyl-coenzyme M reductase I subunit beta 2.8.4.1 0.684
3ghw GHWDihydrofolate reductase 1.5.1.3 0.676
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.676
3dfr MTXDihydrofolate reductase 1.5.1.3 0.674
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.671
4l9k EHFSerum albumin / 0.666
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.665
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.661
1wkg POI[LysW]-aminoadipate semialdehyde transaminase / 0.660
4isu IKMGlutamate receptor 2 / 0.659
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.656
1w06 W05Isopenicillin N synthase 1.21.3.1 0.656
3zzh NLGProtein ARG5,6, mitochondrial 2.7.2.8 0.656
2y6f M9FIsopenicillin N synthase 1.21.3.1 0.655
1ddr MTXDihydrofolate reductase 1.5.1.3 0.652
4bb3 KKAIsopenicillin N synthase 1.21.3.1 0.652
1drt PCVClavaminate synthase 1 1.14.11.21 0.650
3dat MTXDihydrofolate reductase / 0.650