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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5c03 AGS Non-receptor tyrosine-protein kinase TYK2 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 1.125
4fvq ATPTyrosine-protein kinase JAK2 / 0.855
4fvr ATPTyrosine-protein kinase JAK2 / 0.832
5i4n ATPTyrosine-protein kinase JAK2 / 0.812
2cvx DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.697
3s87 DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.697
3s8a DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.692
2cvu ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.691
3zcb ATPAdenosine monophosphate-protein transferase VbhT 2.7.7.n1 0.690
2xul ATPNitrogen regulatory protein P-II / 0.688
4oi4 ATPmRNA cleavage and polyadenylation factor CLP1 / 0.687
4dtp DGTDNA-directed DNA polymerase / 0.685
4fj5 DTPDNA-directed DNA polymerase / 0.685
1n2e APCPantothenate synthetase 6.3.2.1 0.683
1oe0 TTPDeoxynucleoside kinase / 0.683
4ix5 ANPUncharacterized protein / 0.683
2aky AP5Adenylate kinase / 0.682
3se5 ANPAdenosine monophosphate-protein transferase NmFic 2.7.7.n1 0.678
4dfk 0L5DNA polymerase I, thermostable 2.7.7.7 0.677
4w5j AP5Adenylate kinase / 0.677
3g6x DGTDNA polymerase iota 2.7.7.7 0.675
3v2u ATPProtein GAL3 / 0.674
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.672
4fk4 DGTDNA-directed DNA polymerase / 0.672
4m3t ATPDNA-directed DNA polymerase / 0.672
2a41 ATPActin, alpha skeletal muscle / 0.671
4u03 GTPCyclic GMP-AMP synthase / 0.671
4xj4 3ATCyclic GMP-AMP synthase / 0.671
4c0b ATPmRNA cleavage and polyadenylation factor CLP1 / 0.670
4fjh DGTDNA-directed DNA polymerase / 0.670
4qm6 GTPMetallophosphoesterase / 0.670
3m0e ATPTranscriptional regulator (NtrC family) / 0.669
4ww9 ADPEKC/KEOPS complex subunit BUD32 3.6 0.667
3ne6 DCPDNA-directed DNA polymerase / 0.666
3zlm ANPAdenosine monophosphate-protein transferase NmFic 2.7.7.n1 0.666
4mkf AP5Adenylate kinase / 0.666
4xj3 GTPCyclic GMP-AMP synthase / 0.666
1svm ATPLarge T antigen 3.6.4 0.665
4m3x ATPDNA-directed DNA polymerase / 0.665
4tyq AP5Adenylate kinase / 0.665
4dtj TTPDNA-directed DNA polymerase / 0.664
4khy TTPDNA-directed DNA polymerase / 0.664
1rfq ATPActin, alpha skeletal muscle / 0.663
1ayl ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.662
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.662
3er9 3ATPoly(A) polymerase catalytic subunit 2.7.7.19 0.662
4dtx TTPDNA-directed DNA polymerase / 0.662
4txz G2PCyclic GMP-AMP synthase / 0.662
1atn ATPActin, alpha skeletal muscle / 0.661
3mhy ATPNitrogen regulatory protein P-II 1 / 0.661
3bxz ADPProtein translocase subunit SecA / 0.660
2olr ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.659
3a5o ATPMajor actin / 0.659
4kqs RISFarnesyl pyrophosphate synthase 2.5.1.10 0.659
4qfx DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.659
2eu8 AP5Adenylate kinase / 0.658
1r0z ATPCystic fibrosis transmembrane conductance regulator / 0.657
3w3d ATPActin, gamma-enteric smooth muscle / 0.657
4ol0 GTPGTP-binding nuclear protein Ran / 0.657
1xs4 DCPdCTP deaminase / 0.656
3k8t DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.656
4ffb GTPTubulin alpha-1 chain / 0.655
4iij GTPTubulin alpha-1B chain / 0.655
1n2g APCPantothenate synthetase 6.3.2.1 0.654
4dca ADPAminoglycoside phosphotransferase / 0.654
4yj2 GTPTubulin alpha-1B chain / 0.654
1wua ATPActin, alpha skeletal muscle / 0.653
2v51 ATPActin, alpha skeletal muscle / 0.653
3wt0 ATPCell division protein FtsA / 0.653
4f1m ACPProbable serine/threonine-protein kinase roco4 2.7.11.1 0.652
4ix6 ADPUncharacterized protein / 0.652
4r39 ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.652
1i44 ACPInsulin receptor 2.7.10.1 0.651
1kxp ATPActin, alpha skeletal muscle / 0.651
1ol6 ATPAurora kinase A 2.7.11.1 0.651
2hf8 GSPProbable hydrogenase nickel incorporation protein HypB / 0.651
2pup ADPMethylthioribose kinase 2.7.1.100 0.651
2we3 DUTDeoxyuridine 5'-triphosphate nucleotidohydrolase / 0.651
2z78 H86Geranylgeranyl pyrophosphate synthase / 0.650
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.650
4o4l GTPTubulin alpha-1B chain / 0.650
4xvu ATPATPase GET3 / 0.650