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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5bsf NAD Pyrroline-5-carboxylate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5bsf NADPyrroline-5-carboxylate reductase / 1.075
5bsg NAPPyrroline-5-carboxylate reductase / 0.940
2rcy NAPPyrroline-5-carboxylate reductase / 0.734
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.723
1zh8 NAPUncharacterized protein / 0.720
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 0.707
5a03 NDPGlucose-fructose oxidoreductase / 0.703
5a04 NDPGlucose-fructose oxidoreductase / 0.703
1ofg NDPGlucose--fructose oxidoreductase 1.1.99.28 0.702
2ahr NAPPyrroline-5-carboxylate reductase / 0.702
5a06 NDPGlucose-fructose oxidoreductase / 0.693
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.692
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.690
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.690
2qtr NXXProbable nicotinate-nucleotide adenylyltransferase / 0.689
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.688
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.682
4wso NADProbable nicotinate-nucleotide adenylyltransferase / 0.680
4xqc NADHomospermidine synthase 2.5.1.44 0.678
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.677
3tri NAPPyrroline-5-carboxylate reductase / 0.676
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.676
2glx NDP1,5-anhydro-D-fructose reductase / 0.674
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.674
4xgi NADGlutamate dehydrogenase / 0.674
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.672
4plp NADHomospermidine synthase 2.5.1.44 0.672
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.672
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.669
5a05 NDPGlucose-fructose oxidoreductase / 0.669
1t2a NDPGDP-mannose 4,6 dehydratase 4.2.1.47 0.668
2h2a DNDProbable nicotinate-nucleotide adenylyltransferase / 0.668
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.666
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.666
2pv7 NADT-protein 1.3.1.12 0.665
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.665
4jk3 NADUncharacterized protein / 0.665
3m2t NADProbable dehydrogenase / 0.664
2xaa NADSecondary alcohol dehydrogenase / 0.663
3ggp NADPrephenate dehydrogenase / 0.663
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.663
2vyv NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.661
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.661
3wfj NAD2-dehydropantoate 2-reductase / 0.661
2axn ADP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 / 0.658
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.656
2voj NADAlanine dehydrogenase 1.4.1.1 0.654
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.654
2gv8 NDPThiol-specific monooxygenase 1.14.13 0.653
2o4c NADErythronate-4-phosphate dehydrogenase / 0.652
2yjz NAPMetalloreductase STEAP4 1.16.1 0.652
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.652
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.652
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.651
4xb2 NDP319aa long hypothetical homoserine dehydrogenase / 0.651
4xq9 NADHomospermidine synthase 2.5.1.44 0.651
1lj8 NADMannitol dehydrogenase / 0.650
2vhx NADAlanine dehydrogenase 1.4.1.1 0.650
3hl4 CDCCholine-phosphate cytidylyltransferase A / 0.650