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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5aaa VGH ALK tyrosine kinase receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5aaa VGHALK tyrosine kinase receptor 2.7.10.1 1.044
5aab VGHALK tyrosine kinase receptor 2.7.10.1 0.989
2xp2 VGHALK tyrosine kinase receptor 2.7.10.1 0.964
4anq VGHALK tyrosine kinase receptor 2.7.10.1 0.947
2yfx VGHALK tyrosine kinase receptor 2.7.10.1 0.935
4ans VGHALK tyrosine kinase receptor 2.7.10.1 0.914
4ccb OFGALK tyrosine kinase receptor 2.7.10.1 0.903
5aac VGHALK tyrosine kinase receptor 2.7.10.1 0.878
4cd0 AWJALK tyrosine kinase receptor 2.7.10.1 0.844
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4ccu AWFALK tyrosine kinase receptor 2.7.10.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2xba 571ALK tyrosine kinase receptor 2.7.10.1 0.655
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.654