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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5a4k FAD NAD(P)H dehydrogenase [quinone] 1 1.6.5.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5a4k FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.273
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.190
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.183
1h66 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.165
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.122
1dxo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.117
1kbo FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.115
1gg5 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.110
1h69 FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.085
5eai FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 1.070
4zvn FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.045
4zvl FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.028
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.027
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.024
3g5m FADRibosyldihydronicotinamide dehydrogenase [quinone] / 1.008
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.985
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.912
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.877
4gi5 FADPutative NAD(P)H dehydrogenase (Quinone) / 0.863
3klb FMNUncharacterized protein / 0.794
3rpe FADPutative modulator of drug activity / 0.789
4m0c FMNFMN-dependent NADH-azoreductase 1 / 0.781
4j8p FMNFlavodoxin / 0.770
3lcm FADPutative oxidoreductase / 0.761
3w77 FMNFMN-dependent NADH-azoreductase / 0.743
3zho FMNNAD(P)H dehydrogenase (quinone) / 0.739
2ohj FMNType A flavoprotein FprA 1 0.735
4dy4 FMNNAD(P)H dehydrogenase (quinone) / 0.720
2z9d FMNFMN-dependent NADH-azoreductase / 0.717
2pg0 FADAcyl-CoA dehydrogenase / 0.714
1zwl FMNNAD(P)H dehydrogenase (quinone) 1.6.5.2 0.713
1t5b FMNFMN-dependent NADH-azoreductase / 0.711
2hpv FMNFMN-dependent NADH-azoreductase 1.7 0.710
4r81 FMNPredicted NADH dehydrogenase / 0.710
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.709
2r97 FMNNAD(P)H dehydrogenase (quinone) / 0.708
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.708
4cw5 FMNDfnA / 0.707
1vhn FMNtRNA-dihydrouridine synthase / 0.706
2gjn FMNNitronate monooxygenase 1.13.12.16 0.701
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 0.701
4utl FNRXenobiotic reductase / 0.701
4n9q FMNFMN-dependent NADH-azoreductase 1 / 0.700
4n65 FMNFMN-dependent NADH-azoreductase 1 / 0.699
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 0.697
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.692
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 0.690
4utm FNRXenobiotic reductase / 0.690
4hs4 FMNChromate reductase / 0.689
3n19 FNRXenobiotic reductase / 0.688
4utk FNRXenobiotic reductase / 0.688
2gjl FMNNitronate monooxygenase 1.13.12.16 0.687
1ycg FMNNitric oxide reductase 1 0.686
2h8x FMNXenA / 0.686
1gwj FMNMorphinone reductase / 0.685
3l5l FMNXenobiotic reductase / 0.685
4tmb FMNOld yellow enzyme / 0.684
3n3b FMNProtein NrdI / 0.683
4tmc FMNOld yellow enzyme / 0.683
2isl FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.680
4e2d FMNDehydrogenase / 0.678
3gka FMNN-ethylmaleimide reductase / 0.677
2isk FNR5,6-dimethylbenzimidazole synthase 1.13.11.79 0.676
4jic FMNGTN Reductase / 0.676
3atz FMNProstaglandin F2a synthase / 0.674
4bmo FMNProtein NrdI / 0.674
4yco FMNtRNA-dihydrouridine(16) synthase / 0.674
1vyr FMNPentaerythritol tetranitrate reductase / 0.672
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.671
1t9g FADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial 1.3.8.7 0.671
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.670
4awt FMNNADH:flavin oxidoreductase Sye1 / 0.670
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.670
2z6i FMN2-nitropropane dioxygenase / 0.669
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.669
1buc FADAcyl-CoA dehydrogenase, short-chain specific 1.3.8.1 0.668
1azl FMNFlavodoxin / 0.665
2jk6 FADTrypanothione reductase / 0.665
2abb FMNPentaerythritol tetranitrate reductase / 0.664
2q3o FMN12-oxophytodienoate reductase 3 1.3.1.42 0.664
1h63 FMNPentaerythritol tetranitrate reductase / 0.663
5f12 FMNNAD(P)H dehydrogenase (quinone) / 0.663
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 0.662
4n82 FMNRibonucleotide reductase (NrdI family protein), putative / 0.662
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.661
3l67 FMNXenobiotic reductase / 0.661
3tjl FMNNADPH dehydrogenase / 0.660
4m5p FMNNADPH dehydrogenase / 0.660
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.660
1rx0 FADIsobutyryl-CoA dehydrogenase, mitochondrial 1.3.99 0.659
3sf6 FDAGlutaryl-CoA dehydrogenase / 0.659
4uth FMNXenobiotic reductase / 0.659
1akw FMNFlavodoxin / 0.658
4l82 FMNUncharacterized protein / 0.658
4mih FADPyranose 2-oxidase 1.1.3.10 0.658
1akr FMNFlavodoxin / 0.657
4df2 FMNNADPH dehydrogenase / 0.657
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.656
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.656
3qe2 FMNNADPH--cytochrome P450 reductase / 0.656
4aut FADDecaprenylphosphoryl-beta-D-ribose oxidase / 0.656
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.655
2bf4 FMNNADPH--cytochrome P450 reductase / 0.655
2z6c FMNPhototropin-1 2.7.11.1 0.654
3f90 FMNFlavodoxin / 0.654
3p67 FMNPentaerythritol tetranitrate reductase / 0.654
3p8i FMNPentaerythritol tetranitrate reductase / 0.653
1h51 FMNPentaerythritol tetranitrate reductase / 0.652
3f03 FMNPentaerythritol tetranitrate reductase / 0.652
3p84 FMNPentaerythritol tetranitrate reductase / 0.652
3p8j FMNPentaerythritol tetranitrate reductase / 0.652
4bmp FMNProtein NrdI / 0.652
4e2b FMNDehydrogenase / 0.652
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.651
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.651
2b3d FADModulator of drug activity B / 0.650
2r96 FMNNAD(P)H dehydrogenase (quinone) / 0.650
2reh FADNitroalkane oxidase 1.7.3.1 0.650
4j57 FADThioredoxin reductase 2 1.8.1.9 0.650
5jsc FADPutative acyl-CoA dehydrogenase / 0.650