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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4zse ANP Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4zse ANPEpidermal growth factor receptor 2.7.10.1 1.031
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.843
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.829
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.822
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 0.820
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.812
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.810
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.772
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.766
1hck ATPCyclin-dependent kinase 2 2.7.11.22 0.728
1b39 ATPCyclin-dependent kinase 2 2.7.11.22 0.708
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.707
3ork AGSSerine/threonine protein kinase / 0.697
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.694
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.691
4riy ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.689
3rep ATPIntegrin-linked protein kinase 2.7.11.1 0.685
1zyd ATPeIF-2-alpha kinase GCN2 / 0.669
2ozo ANPTyrosine-protein kinase ZAP-70 2.7.10.2 0.669
4xhg ADPUncharacterized protein / 0.666
1n75 ATPGlutamate--tRNA ligase 6.1.1.17 0.663
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.663
1r6t TYMTryptophan--tRNA ligase, cytoplasmic 6.1.1.2 0.661
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.661
4fvq ATPTyrosine-protein kinase JAK2 / 0.658
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.657
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.657
4ipe ANPTNF receptor-associated protein 1 / 0.654
4ivg ANPTNF receptor-associated protein 1 / 0.654
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.653
1xjk DGTVitamin B12-dependent ribonucleotide reductase / 0.652
3ruq ADPChaperonin / 0.652
4mv8 ACPBiotin carboxylase 6.3.4.14 0.652
3t0z ATPHeat shock protein HSP 90-alpha / 0.651