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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4x5j FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4x5j FOLDihydrofolate reductase 1.5.1.3 0.825
4e5i 0N9Polymerase acidic protein / 0.744
4x5h FOLDihydrofolate reductase 1.5.1.3 0.731
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.701
4x5i FOLDihydrofolate reductase 1.5.1.3 0.696
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.695
1dyh DZFDihydrofolate reductase 1.5.1.3 0.689
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.688
4x5f FOLDihydrofolate reductase 1.5.1.3 0.681
1dyi FOLDihydrofolate reductase 1.5.1.3 0.679
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.677
4kjj FOLDihydrofolate reductase 1.5.1.3 0.676
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.673
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.665
4x5g FOLDihydrofolate reductase 1.5.1.3 0.663
4e5f 0N7Polymerase acidic protein / 0.660
4i13 FOLDihydrofolate reductase 1.5.1.3 0.656
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.655
1re7 FOLDihydrofolate reductase 1.5.1.3 0.655
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.653
2zza FOLDihydrofolate reductase / 0.652