Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4s33 ANP Mitogen-activated protein kinase 1 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.964
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.771
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.749
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.737
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.736
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.736
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.734
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.731
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.731
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.731
3tw6 ADPPyruvate carboxylase / 0.725
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.717
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.717
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.716
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.714
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.712
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.707
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.707
4xlv ACPInsulin receptor 2.7.10.1 0.707
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.706
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.706
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.702
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.701
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.700
2pzp ACPFibroblast growth factor receptor 2 / 0.699
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.693
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.692
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.692
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.691
3bu5 ATPInsulin receptor 2.7.10.1 0.691
2py3 ACPFibroblast growth factor receptor 2 / 0.690
5eg3 ACPFibroblast growth factor receptor 2 / 0.688
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.687
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.687
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.686
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.685
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.685
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.685
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.685
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.685
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.683
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.683
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.683
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.683
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.682
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.681
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.681
3cly ACPFibroblast growth factor receptor 2 / 0.680
2pup ADPMethylthioribose kinase 2.7.1.100 0.678
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.677
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.676
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.676
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.676
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.675
2pml ANPUncharacterized protein / 0.674
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.673
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.672
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.672
2pz5 ACPFibroblast growth factor receptor 2 / 0.671
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.671
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.670
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.670
4uya AGSMitogen-activated protein kinase kinase kinase 21 2.7.11.25 0.670
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
5dt3 ATPAurora kinase A 2.7.11.1 0.669
1ol5 ADPAurora kinase A 2.7.11.1 0.668
1px2 ATPSynapsin-1 / 0.668
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.668
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.667
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.667
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.667
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.665
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.664
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.664
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.664
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.664
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.664
2wqe ADPAurora kinase A 2.7.11.1 0.663
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.662
5dn3 ATPAurora kinase A 2.7.11.1 0.662
1cm8 ANPMitogen-activated protein kinase 12 / 0.661
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.661
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4utd ACPAurora kinase A 2.7.11.1 0.660
2dv7 SAHDiphthine synthase / 0.659
1jdb ADPCarbamoyl-phosphate synthase large chain / 0.658
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.658
1m0w ANPGlutathione synthetase 6.3.2.3 0.657
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.657
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.657
2zdg ADPD-alanine--D-alanine ligase / 0.657
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.657
2hgs ADPGlutathione synthetase 6.3.2.3 0.656
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3a8w ATPProtein kinase C iota type 2.7.11.13 0.656
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.656
5l8j ADPAurora kinase A 2.7.11.1 0.656
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.655
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.655
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.655
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.654
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.653
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.653
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.652
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.652
2pui ADPMethylthioribose kinase 2.7.1.100 0.652
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.652
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.652
2eeq SAHDiphthine synthase / 0.651
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.650