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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4rwn APC 2'-5'-oligoadenylate synthase 1 2.7.7.84

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4rwn APC2'-5'-oligoadenylate synthase 1 2.7.7.84 1.097
2q66 ATPPoly(A) polymerase 2.7.7.19 0.803
4k97 ATPCyclic GMP-AMP synthase / 0.787
3q23 G2PVirion DNA-directed RNA polymerase / 0.783
2b56 UTPRNA editing complex protein MP57 / 0.774
4dtp DGTDNA-directed DNA polymerase / 0.770
4m42 ATPDNA-directed DNA polymerase / 0.767
4xj4 3ATCyclic GMP-AMP synthase / 0.766
3hiy UTPUncharacterized protein / 0.763
4fj5 DTPDNA-directed DNA polymerase / 0.761
3ne6 DCPDNA-directed DNA polymerase / 0.759
3sup DCPDNA-directed DNA polymerase / 0.749
4fjh DGTDNA-directed DNA polymerase / 0.748
4fjm DCPDNA-directed DNA polymerase / 0.748
4fjj TTPDNA-directed DNA polymerase / 0.747
4dtj TTPDNA-directed DNA polymerase / 0.746
3g6x DGTDNA polymerase iota 2.7.7.7 0.745
4fjl DGTDNA-directed DNA polymerase / 0.742
4fk4 DGTDNA-directed DNA polymerase / 0.742
4dfk 0L5DNA polymerase I, thermostable 2.7.7.7 0.740
4dtx TTPDNA-directed DNA polymerase / 0.728
2b51 UTPRNA editing complex protein MP57 / 0.727
4df8 0L4DNA polymerase I, thermostable 2.7.7.7 0.726
4xj3 GTPCyclic GMP-AMP synthase / 0.726
3au2 DGTDNA polymerase beta family (X family) / 0.724
4khy TTPDNA-directed DNA polymerase / 0.722
4df4 0L3DNA polymerase I, thermostable 2.7.7.7 0.721
3lzj CTPDNA-directed DNA polymerase / 0.720
1r89 CTPCCA-adding enzyme 2.7.7.72 0.717
4u03 GTPCyclic GMP-AMP synthase / 0.708
4m3t ATPDNA-directed DNA polymerase / 0.707
4m3x ATPDNA-directed DNA polymerase / 0.694
4xul GTPUncharacterized protein mg662 / 0.692
3ova APCCCA-adding enzyme 2.7.7.72 0.687
1zm7 TTPDeoxynucleoside kinase / 0.685
2zh6 ATPCCA-adding enzyme 2.7.7.72 0.685
1r8b ATPCCA-adding enzyme 2.7.7.72 0.684
1r8c UTPCCA-adding enzyme 2.7.7.72 0.682
2q0c CTPPoly(A) polymerase, putative / 0.682
3m0e ATPTranscriptional regulator (NtrC family) / 0.679
2dra ATPCCA-adding enzyme 2.7.7.72 0.678
2ikf UTPPoly(A) polymerase, putative / 0.677
4txz G2PCyclic GMP-AMP synthase / 0.675
3w2w ATPCRISPR system Cmr subunit Cmr2 / 0.674
4ptf DCPDNA polymerase epsilon catalytic subunit A 2.7.7.7 0.673
4ig8 DTP2'-5'-oligoadenylate synthase 1 / 0.672
4dtm DCPDNA-directed DNA polymerase / 0.671
3wbz ATPtRNA(His) guanylyltransferase {ECO:0000256|PIRNR:PIRNR028980} / 0.668
4fvq ATPTyrosine-protein kinase JAK2 / 0.665
5a2w AGSMitochondrial poly(A) polymerase / 0.665
4aff ATPNitrogen regulatory protein P-II / 0.662
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.661
1foa UD1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase 2.4.1.101 0.660
2j0s ANPEukaryotic initiation factor 4A-III 3.6.4.13 0.657
3er9 3ATPoly(A) polymerase catalytic subunit 2.7.7.19 0.657
1kek HTLPyruvate synthase / 0.656
3lbn GNPGTPase HRas / 0.656
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.656
4dto DCPDNA-directed DNA polymerase / 0.655
3ov7 ATPCCA-adding enzyme 2.7.7.72 0.654
3mhy ATPNitrogen regulatory protein P-II 1 / 0.653
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.653
5i4n ATPTyrosine-protein kinase JAK2 / 0.653
1t91 GTPRas-related protein Rab-7a / 0.651
3ahe THDProbable phosphoketolase / 0.651
2c42 TPPPyruvate synthase / 0.650
3tkl GTPRas-related protein Rab-1A / 0.650