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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4qmn DB8 Serine/threonine-protein kinase 24 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4qmn DB8Serine/threonine-protein kinase 24 2.7.11.1 0.994
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.764
3ue4 DB8Tyrosine-protein kinase ABL1 2.7.10.2 0.756
4qmx H8HSerine/threonine-protein kinase 24 2.7.11.1 0.749
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4e5l DBHPolymerase acidic protein / 0.744
4ek9 EP4Histone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.744
4mxy DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.730
4mxz DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.730
5ajq DB8Serine/threonine-protein kinase 10 2.7.11.1 0.723
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.714
4bc6 XZNSerine/threonine-protein kinase 10 2.7.11.1 0.706
3f5p 741Insulin-like growth factor 1 receptor 2.7.10.1 0.680
3unj 0BXCyclin-dependent kinase 2 2.7.11.22 0.672
4qms 1N1Serine/threonine-protein kinase 24 2.7.11.1 0.669
4mxx DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.667
2vwu 7X1Ephrin type-B receptor 4 2.7.10.1 0.665
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pot GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4h7z GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hvx QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
2ivu ZD6Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.653
2zm1 KSFTyrosine-protein kinase Lck 2.7.10.2 0.653