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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4p68 MTX Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4p68 MTXDihydrofolate reductase / 0.927
4p66 MTXDihydrofolate reductase / 0.819
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.780
1df7 MTXDihydrofolate reductase 1.5.1.3 0.776
3ia4 MTXDihydrofolate reductase / 0.776
3drc MTXDihydrofolate reductase 1.5.1.3 0.772
3eig MTXDihydrofolate reductase 1.5.1.3 0.767
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.763
1dre MTXDihydrofolate reductase 1.5.1.3 0.759
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.758
1u70 MTXDihydrofolate reductase 1.5.1.3 0.758
3dau MTXDihydrofolate reductase 1.5.1.3 0.755
5hi6 MTXDihydrofolate reductase / 0.754
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.753
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.740
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.739
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.736
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.734
3ghv GHCDihydrofolate reductase 1.5.1.3 0.733
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.732
1e26 GPBDihydrofolate reductase 1.5.1.3 0.730
4x5f FOLDihydrofolate reductase 1.5.1.3 0.729
1dra MTXDihydrofolate reductase 1.5.1.3 0.727
2drc MTXDihydrofolate reductase 1.5.1.3 0.726
7dfr FOLDihydrofolate reductase 1.5.1.3 0.726
3och 2MXDihydrofolate reductase 1.5.1.3 0.725
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.724
3ghw GHWDihydrofolate reductase 1.5.1.3 0.722
4qi9 MTXDihydrofolate reductase / 0.722
1ddr MTXDihydrofolate reductase 1.5.1.3 0.719
2qk8 MTXDihydrofolate reductase / 0.718
1tdr MTXDihydrofolate reductase 1.5.1.3 0.717
1u72 MTXDihydrofolate reductase 1.5.1.3 0.717
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.716
4keb FOLDihydrofolate reductase 1.5.1.3 0.715
1hfq MOTDihydrofolate reductase 1.5.1.3 0.714
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.713
1dhi MTXDihydrofolate reductase 1.5.1.3 0.711
1hfp MOTDihydrofolate reductase 1.5.1.3 0.710
1hfr MOTDihydrofolate reductase 1.5.1.3 0.710
1dhj MTXDihydrofolate reductase 1.5.1.3 0.709
1drb MTXDihydrofolate reductase 1.5.1.3 0.709
2d0k FOLDihydrofolate reductase 1.5.1.3 0.709
1dls MTXDihydrofolate reductase 1.5.1.3 0.707
4dfr MTXDihydrofolate reductase 1.5.1.3 0.705
1jom FFODihydrofolate reductase 1.5.1.3 0.702
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.702
3dfr MTXDihydrofolate reductase 1.5.1.3 0.702
3td8 D2RDihydrofolate reductase 1.5.1.3 0.698
1dyj DDFDihydrofolate reductase 1.5.1.3 0.697
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.697
3frd DHFDihydrofolate reductase 1.5.1.3 0.697
5ccc DDFDihydrofolate reductase 1.5.1.3 0.697
4kfj FOLDihydrofolate reductase 1.5.1.3 0.696
4m6k FOLDihydrofolate reductase 1.5.1.3 0.696
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.696
2w3m FOLDihydrofolate reductase 1.5.1.3 0.695
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.695
1dyh DZFDihydrofolate reductase 1.5.1.3 0.694
1dyi FOLDihydrofolate reductase 1.5.1.3 0.694
1re7 FOLDihydrofolate reductase 1.5.1.3 0.691
4x5i FOLDihydrofolate reductase 1.5.1.3 0.690
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.688
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.688
4kjj FOLDihydrofolate reductase 1.5.1.3 0.688
1ohj COPDihydrofolate reductase 1.5.1.3 0.687
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.685
1jol FFODihydrofolate reductase 1.5.1.3 0.684
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.684
3dat MTXDihydrofolate reductase / 0.683
1dhf FOLDihydrofolate reductase 1.5.1.3 0.682
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.682
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.681
4x5g FOLDihydrofolate reductase 1.5.1.3 0.681
2zza FOLDihydrofolate reductase / 0.680
4i13 FOLDihydrofolate reductase 1.5.1.3 0.680
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.679
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.678
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.678
1dds MTXDihydrofolate reductase 1.5.1.3 0.676
4m6l 21VDihydrofolate reductase 1.5.1.3 0.676
2tpl HPPTyrosine phenol-lyase 4.1.99.2 0.675
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.675
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.673
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.672
4ie0 PD2Alpha-ketoglutarate-dependent dioxygenase FTO / 0.672
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.671
3jwc EKBDihydrofolate reductase / 0.671
1drf FOLDihydrofolate reductase 1.5.1.3 0.670
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.670
1daj MOTDihydrofolate reductase 1.5.1.3 0.669
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.668
4ixg IXGDihydrofolate reductase 1.5.1.3 0.667
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.666
1s3w TQTDihydrofolate reductase 1.5.1.3 0.665
1s3v TQDDihydrofolate reductase 1.5.1.3 0.663
4i1n FOLDihydrofolate reductase 1.5.1.3 0.661
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.660
2dhf DZFDihydrofolate reductase 1.5.1.3 0.658
3eem 53VUncharacterized protein / 0.658
1drt PCVClavaminate synthase 1 1.14.11.21 0.657
3i8a N22Dihydrofolate reductase 1.5.1.3 0.657
4fgg 0U5Dihydrofolate reductase 1.5.1.3 0.655
4i8x 6P3L-lactate dehydrogenase A chain 1.1.1.27 0.655
4x5h FOLDihydrofolate reductase 1.5.1.3 0.655
3zku HCVIsopenicillin N synthase 1.21.3.1 0.654
4dph P65Bifunctional dihydrofolate reductase-thymidylate synthase / 0.652
3cse N22Uncharacterized protein / 0.651
3k45 51PDihydrofolate reductase 1.5.1.3 0.651
1ly3 COGDihydrofolate reductase 1.5.1.3 0.650
3jsu KA5Bifunctional dihydrofolate reductase-thymidylate synthase / 0.650
4ixf IXFDihydrofolate reductase 1.5.1.3 0.650