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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4oea DHT Androgen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4oea DHTAndrogen receptor / 1.156
4oey DHTAndrogen receptor / 1.136
2ama DHTAndrogen receptor / 1.131
1t79 DHTAndrogen receptor / 1.128
4oez DHTAndrogen receptor / 1.125
1t73 DHTAndrogen receptor / 1.123
1t74 DHTAndrogen receptor / 1.123
2pit DHTAndrogen receptor / 1.123
2pio DHTAndrogen receptor / 1.122
1t7r DHTAndrogen receptor / 1.107
1t65 DHTAndrogen receptor / 1.094
2pip DHTAndrogen receptor / 1.089
1t5z DHTAndrogen receptor / 1.085
4ofr DHTAndrogen receptor / 1.071
2pkl DHTAndrogen receptor / 1.068
4oed DHTAndrogen receptor / 1.052
2piw DHTAndrogen receptor / 1.030
2q7i TESAndrogen receptor / 1.028
2piq DHTAndrogen receptor / 1.027
2pix DHTAndrogen receptor / 1.019
2ylp TESAndrogen receptor / 1.011
1t7m DHTAndrogen receptor / 1.000
4hlw TESAndrogen receptor / 0.983
2z4j DHTAndrogen receptor / 0.977
1t76 DHTAndrogen receptor / 0.976
2q7k TESAndrogen receptor / 0.974
1t7f DHTAndrogen receptor / 0.964
2pnu ENMAndrogen receptor / 0.871
1t7t DHTAndrogen receptor / 0.852
4ofu DHTAndrogen receptor / 0.847
1t63 DHTAndrogen receptor / 0.834
2piu DHTAndrogen receptor / 0.834
2piv DHTAndrogen receptor / 0.820
2amb 17HAndrogen receptor / 0.814
2pir DHTAndrogen receptor / 0.810
1xj7 DHTAndrogen receptor / 0.809
1xow R18Androgen receptor / 0.780
2am9 TESAndrogen receptor / 0.777
2ylq TESAndrogen receptor / 0.777
2ao6 R18Androgen receptor / 0.775
2q7l TESAndrogen receptor / 0.769
1gs4 ZK5Androgen receptor / 0.764
4e5l DBHPolymerase acidic protein / 0.760
2qpy DHTAndrogen receptor / 0.746
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4k7a DHTAndrogen receptor / 0.735
2q7j TESAndrogen receptor / 0.727
2ylo TESAndrogen receptor / 0.719
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.699
1qyw 5SDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.697
1xq3 R18Androgen receptor / 0.696
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 0.682
1xu7 CPSCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.680
2d09 FLVBiflaviolin synthase CYP158A2 / 0.679
3f3y 4OABile salt sulfotransferase 2.8.2.14 0.678
2yja ESTEstrogen receptor / 0.672
1jtv TESEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.670
2yhd TESAndrogen receptor / 0.670
1lho AOMSex hormone-binding globulin / 0.669
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.669
4at2 ASDPossible succinate dehydrogenase / 0.666
4jvl ESTEstrogen sulfotransferase 2.8.2.4 0.666
1lri CLRBeta-elicitin cryptogein / 0.665
2ocf ESTEstrogen receptor / 0.663
3g1r FIT3-oxo-5-beta-steroid 4-dehydrogenase / 0.662
4e5f 0N7Polymerase acidic protein / 0.660
4qe6 JN3Bile acid receptor / 0.660
2j7x ESTEstrogen receptor beta / 0.658
3cmf PDN3-oxo-5-beta-steroid 4-dehydrogenase / 0.658
1osv CHCBile acid receptor / 0.657
1lhn AONSex hormone-binding globulin / 0.652
2aax PDNMineralocorticoid receptor / 0.652