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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4o0w ADN Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4o0w ADNAurora kinase A 2.7.11.1 0.783
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4o0s ADNAurora kinase A 2.7.11.1 0.735
1mq4 ADPAurora kinase A 2.7.11.1 0.712
4ceg ADPAurora kinase A 2.7.11.1 0.701
4dee ADPAurora kinase A 2.7.11.1 0.700
5dr2 ATPAurora kinase A 2.7.11.1 0.699
2dwb ANPAurora kinase A 2.7.11.1 0.697
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.696
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4o0u ADNAurora kinase A 2.7.11.1 0.687
4qny ANPMitogen activated protein kinase, putative / 0.684
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.681
5dn3 ATPAurora kinase A 2.7.11.1 0.681
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4utd ACPAurora kinase A 2.7.11.1 0.678
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
1rfu ADPPyridoxal kinase 2.7.1.35 0.675
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.674
1ol5 ADPAurora kinase A 2.7.11.1 0.674
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4ysj ADPCalmodulin-like domain protein kinase / 0.673
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4bn1 ADPAurora kinase A 2.7.11.1 0.672
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.670
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.669
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.669
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.668
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
5ce3 ADPProtein kinase YopO / 0.666
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.664
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.663
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.663
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.661
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.660
4e5f 0N7Polymerase acidic protein / 0.660
2wqe ADPAurora kinase A 2.7.11.1 0.659
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.659
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.658
5dt3 ATPAurora kinase A 2.7.11.1 0.658
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.657
3cly ACPFibroblast growth factor receptor 2 / 0.657
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.657
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.655
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.655
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.655
5dt4 ATPAurora kinase A 2.7.11.1 0.655
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.654
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.654
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.653
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.653
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.651
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.651
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.650
4o1p ANPRibonuclease L / 0.650