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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mxe ACO N-acetyltransferase ESCO1 2.3.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mxe ACON-acetyltransferase ESCO1 2.3.1 1.361
2c27 ACOMycothiol acetyltransferase 2.3.1.189 0.858
4hkf ACOAlpha-tubulin N-acetyltransferase 1 / 0.830
2psw COAN-alpha-acetyltransferase 50 / 0.793
3to6 LYS_CMCHistone acetyltransferase ESA1 / 0.786
2cy2 ACOProbable acetyltransferase / 0.783
4ag7 COAGlucosamine 6-phosphate N-acetyltransferase / 0.775
1p0h ACOMycothiol acetyltransferase 2.3.1.189 0.773
1mja COAHistone acetyltransferase ESA1 / 0.771
1mj9 COAHistone acetyltransferase ESA1 / 0.769
2bsw CAOProbable acetyltransferase / 0.767
1mjb ACOHistone acetyltransferase ESA1 / 0.766
4cry ACOPanD regulatory factor / 0.764
2ozu ACOHistone acetyltransferase KAT6A / 0.763
4crz ACOPanD regulatory factor / 0.758
3s6f COAUncharacterized protein / 0.756
4r3k COAN-alpha-acetyltransferase 2.3.1 0.754
2vbq BSJAminoglycoside N(6')-acetyltransferase type 1 / 0.749
3vwe COAAlpha-tubulin N-acetyltransferase 1 / 0.748
2jdc CAOProbable acetyltransferase / 0.744
1fy7 COAHistone acetyltransferase ESA1 / 0.741
1s3z COAAminoglycoside N(6')-acetyltransferase type 1 / 0.740
2jdd ACOProbable acetyltransferase / 0.739
4zm6 ACON-acetyl-beta-D glucosaminidase / 0.739
2vxk COAGlucosamine 6-phosphate acetyltransferase, putative / 0.738
2ou2 ACOHistone acetyltransferase KAT5 / 0.736
1qsm ACOHistone acetyltransferase HPA2 / 0.735
4qvt ACOAcetyltransferase YpeA 2.3.1 0.735
2giv ACOHistone acetyltransferase KAT8 / 0.728
4xnh ACON-terminal acetyltransferase A complex subunit NAT5 2.3.1 0.727
1l0c COTSerotonin N-acetyltransferase / 0.726
2bei ACODiamine acetyltransferase 2 2.3.1.57 0.726
5kf9 ACOPredicted acetyltransferase / 0.725
4cs0 ACOPanD regulatory factor / 0.724
2y0m ACOHistone acetyltransferase KAT8 / 0.723
1wwz ACOUncharacterized protein / 0.722
2fiw ACOGCN5-related N-acetyltransferase:Aminotransferase, class-II / 0.716
3te4 ACODopamine N-acetyltransferase / 0.716
2rc4 ACOHistone acetyltransferase KAT6A / 0.714
1n71 COAAac(6')-Ii protein / 0.713
4u9z COAAlpha-tubulin N-acetyltransferase 1 / 0.713
3f8k COAUncharacterized protein / 0.710
1z4r ACOHistone acetyltransferase KAT2A 2.3.1.48 0.709
5kf2 ACOPredicted acetyltransferase / 0.709
5kf8 ACOPredicted acetyltransferase / 0.709
1j4j ACOAcetyltransferase 2.3.1 0.707
2a4n COAAac(6')-Ii protein / 0.706
3mgd ACOPredicted acetyltransferase / 0.706
2ob0 ACON-alpha-acetyltransferase 50 / 0.705
2q4v ACODiamine acetyltransferase 2 2.3.1.57 0.705
4jwp ACOGCN5-related N-acetyltransferase / 0.705
1ghe ACOAcetyltransferase 2.3.1 0.703
1m1d LYXHAT A1 / 0.703
5kf1 ACOPredicted acetyltransferase / 0.702
1m4i COAAminoglycoside 2'-N-acetyltransferase 2.3.1 0.701
3d2m COAAmino-acid acetyltransferase / 0.698
5kgp ACOPredicted acetyltransferase / 0.696
2vez ACOGlucosamine 6-phosphate acetyltransferase, putative / 0.695
3f0a ACOSpermidine N(1)-acetyltransferase / 0.695
4kvx ACON-terminal acetyltransferase A complex catalytic subunit ard1 2.3.1.88 0.694
5kgj ACOPredicted acetyltransferase / 0.690
4u9y COAAlpha-tubulin N-acetyltransferase 1 / 0.687
4cgp MYAGlycylpeptide N-tetradecanoyltransferase / 0.686
5h86 BCOHistone acetyltransferase KAT2A 2.3.1.48 0.681
3gya COAGCN5-related N-acetyltransferase / 0.677
2cns ACORibosomal-protein-alanine acetyltransferase / 0.674
3tfy COAN-alpha-acetyltransferase 50 2.3.1 0.674
4lx9 ACON-alpha-acetyltransferase 2.3.1 0.674
1pu9 COAHAT A1 / 0.671
1s5k COAAminoglycoside N(6')-acetyltransferase type 1 / 0.671
2zpa ACOtRNA(Met) cytidine acetyltransferase TmcA / 0.671
3k9u ACOSpermidine N(1)-acetyltransferase / 0.668
1qsr ACOHAT A1 / 0.667
2wsa MYAGlycylpeptide N-tetradecanoyltransferase / 0.667
3gy9 COAGCN5-related N-acetyltransferase / 0.667
4h6z ACOAlpha-tubulin N-acetyltransferase 1 / 0.664
1pua COAHAT A1 / 0.663
4if5 ACOAlpha-tubulin N-acetyltransferase 1 / 0.663
1i12 ACOGlucosamine 6-phosphate N-acetyltransferase / 0.662
1s60 COAAminoglycoside N(6')-acetyltransferase type 1 / 0.662
3dr8 ACOL-methionine sulfoximine/L-methionine sulfone acetyltransferase / 0.661
5h84 1VUHistone acetyltransferase KAT2A 2.3.1.48 0.661
5ag4 MYAGlycylpeptide N-tetradecanoyltransferase / 0.656
3pgp ACOUncharacterized protein / 0.655
4r87 COASpermidine N(1)-acetyltransferase / 0.655
5c88 COAN-alpha-acetyltransferase / 0.653