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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mcv 29K Proto-oncogene tyrosine-protein kinase Src 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mcv 29KProto-oncogene tyrosine-protein kinase Src 2.7.10.2 1.084
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.704
3zm4 22TDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.697
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.683
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.678
2wti WTISerine/threonine-protein kinase Chk2 2.7.11.1 0.667
4e5f 0N7Polymerase acidic protein / 0.660
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.656
2x2m X2MProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.653
4lmu QUESerine/threonine-protein kinase pim-1 2.7.11.1 0.652