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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jr7 GNP Casein kinase II subunit alpha 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 1.118
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.928
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.834
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.832
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.810
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.787
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.785
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.785
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.777
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.773
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.769
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.767
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.767
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.766
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.763
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.762
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.756
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.739
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.737
5ce3 ADPProtein kinase YopO / 0.737
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.728
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.728
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.727
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.721
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.720
5dt3 ATPAurora kinase A 2.7.11.1 0.720
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.717
4gyi ADPUncharacterized protein / 0.715
5dr2 ATPAurora kinase A 2.7.11.1 0.715
5dn3 ATPAurora kinase A 2.7.11.1 0.713
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.711
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.711
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.710
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.709
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.707
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.703
4dee ADPAurora kinase A 2.7.11.1 0.701
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.701
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.696
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.696
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.693
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.690
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.688
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.687
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.687
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.681
3tdw GDPGentamicin resistance protein / 0.680
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.680
3qc9 ADPRhodopsin kinase / 0.678
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.677
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.677
2pyw ADPMethylthioribose kinase 2.7.1.100 0.675
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.675
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.674
2olc ADPMethylthioribose kinase 2.7.1.100 0.674
2pui ADPMethylthioribose kinase 2.7.1.100 0.673
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.669
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.667
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.667
3c50 ADPRhodopsin kinase / 0.666
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.666
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.665
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.665
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.664
4ysj ADPCalmodulin-like domain protein kinase / 0.664
5iqh GNPBifunctional AAC/APH 2.3.1 0.664
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.663
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.662
5iqa GNPBifunctional AAC/APH 2.3.1 0.662
3c4z ADPRhodopsin kinase / 0.661
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.661
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.661
5drd ATPAurora kinase A 2.7.11.1 0.661
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
2pml ANPUncharacterized protein / 0.660
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.658
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.658
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.657
5iqb GNPBifunctional AAC/APH 2.3.1 0.657
5iqe GNPBifunctional AAC/APH 2.3.1 0.656
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.655
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.655
4o4d ATPKinase / 0.655
5byl GCPBifunctional AAC/APH 2.3.1 0.655
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.653
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.653
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.652
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.652
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.652
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.652
3tdv GDPGentamicin resistance protein / 0.651
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.650
2pvl P55Casein kinase II subunit alpha 2.7.11.1 0.650
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4o4f ATPKinase / 0.650