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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4j97 ACP Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4j97 ACPFibroblast growth factor receptor 2 / 0.847
3b2t M33Fibroblast growth factor receptor 2 / 0.711
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.708
3kn5 ANPRibosomal protein S6 kinase alpha-5 2.7.11.1 0.695
4j98 ACPFibroblast growth factor receptor 2 / 0.694
2pzp ACPFibroblast growth factor receptor 2 / 0.681
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.681
2py3 ACPFibroblast growth factor receptor 2 / 0.679
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.671
2pvy ACPFibroblast growth factor receptor 2 / 0.667
2pz5 ACPFibroblast growth factor receptor 2 / 0.663
4c2w ANPAurora kinase B-A 2.7.11.1 0.662
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.661
4gv1 0XZRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.658
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.657
5l8k ADPAurora kinase A 2.7.11.1 0.657
2wmv ZYVSerine/threonine-protein kinase Chk1 2.7.11.1 0.655
1e1v CMGCyclin-dependent kinase 2 2.7.11.22 0.654
2pwl ACPFibroblast growth factor receptor 2 / 0.654
2yee 2ECHeat shock protein HSP 90-alpha / 0.653
4s34 ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
4dca ADPAminoglycoside phosphotransferase / 0.650