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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hjo AQ4 Epidermal growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4hjo AQ4Epidermal growth factor receptor 2.7.10.1 1.080
4i22 IREEpidermal growth factor receptor 2.7.10.1 0.797
2h8h H8HProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.759
1efz PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.744
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1m3q ANGN-glycosylase/DNA lyase 3.2.2 0.744
1v2h GUNPurine nucleoside phosphorylase 2.4.2.1 0.744
2puc GUNHTH-type transcriptional repressor PurR / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2itz IREEpidermal growth factor receptor 2.7.10.1 0.735
4i23 1C9Epidermal growth factor receptor 2.7.10.1 0.692
4otw DB8Receptor tyrosine-protein kinase erbB-3 2.7.10.1 0.685
3w33 W19Epidermal growth factor receptor 2.7.10.1 0.681
3ue4 DB8Tyrosine-protein kinase ABL1 2.7.10.2 0.674
1l2j ETCEstrogen receptor beta / 0.665
1m17 AQ4Epidermal growth factor receptor 2.7.10.1 0.665
3f5p 741Insulin-like growth factor 1 receptor 2.7.10.1 0.663
1ozq PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1p0e PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
1ulb GUNPurine nucleoside phosphorylase 2.4.2.1 0.660
2pwu GUNQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3bld PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4gcx PRFQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
4hqv QEIQueuine tRNA-ribosyltransferase 2.4.2.29 0.660
3mtf A3FActivin receptor type-1 2.7.11.30 0.657
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.656
3unk 0BYCyclin-dependent kinase 2 2.7.11.22 0.656
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.656
4mxo DB8Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.650