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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gca 2X9 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gca 2X9Aldose reductase 1.1.1.21 1.336
3g5e Q74Aldose reductase 1.1.1.21 1.122
1z3n 3NAAldose reductase 1.1.1.21 1.085
2dv0 ZSTAldose reductase 1.1.1.21 0.999
2pdn 47DAldose reductase 1.1.1.21 0.994
2hvo ZSTAldose reductase 1.1.1.21 0.969
2dux ZSTAldose reductase 1.1.1.21 0.954
2pd5 ZSTAldose reductase 1.1.1.21 0.923
2hv5 ZSTAldose reductase 1.1.1.21 0.888
2pdh 47DAldose reductase 1.1.1.21 0.884
2duz ZSTAldose reductase 1.1.1.21 0.878
2fz9 ZSTAldose reductase 1.1.1.21 0.860
1frb ZSTAldose reductase-related protein 2 / 0.859
2hvn ZSTAldose reductase 1.1.1.21 0.856
2pdx ZSTAldose reductase 1.1.1.21 0.855
2pdb ZSTAldose reductase 1.1.1.21 0.845
1t40 ID5Aldose reductase 1.1.1.21 0.839
2fz8 ZSTAldose reductase 1.1.1.21 0.839
2pdm ZSTAldose reductase 1.1.1.21 0.826
2pdi ZSTAldose reductase 1.1.1.21 0.796
2pdf ZSTAldose reductase 1.1.1.21 0.795
2pdg 47DAldose reductase 1.1.1.21 0.775
2pdj 393Aldose reductase 1.1.1.21 0.769
2pdq 47DAldose reductase 1.1.1.21 0.760
3ghu LDTAldose reductase 1.1.1.21 0.760
3ght LDTAldose reductase 1.1.1.21 0.748
2ikj 393Aldose reductase 1.1.1.21 0.746
1iei ZESAldose reductase 1.1.1.21 0.743
2qxw LDTAldose reductase 1.1.1.21 0.732
2i17 LDTAldose reductase 1.1.1.21 0.718
2i16 LDTAldose reductase 1.1.1.21 0.717
1t41 ID5Aldose reductase 1.1.1.21 0.713
3m4h 388Aldose reductase 1.1.1.21 0.706
3t42 3T4Aldose reductase 1.1.1.21 0.705
3ld5 LDTAldose reductase 1.1.1.21 0.703
3ghs LDTAldose reductase 1.1.1.21 0.696
3lbo LDTAldose reductase 1.1.1.21 0.696
3ghr LDTAldose reductase 1.1.1.21 0.695
2pzn 393Aldose reductase 1.1.1.21 0.687
2pdu 393Aldose reductase 1.1.1.21 0.686
3mb9 ZSTAldose reductase 1.1.1.21 0.680
3m0i ZSTAldose reductase 1.1.1.21 0.678
1z89 62PAldose reductase 1.1.1.21 0.665
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.658