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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ftc H6K Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ftc H6KSerine/threonine-protein kinase Chk1 2.7.11.1 0.767
4ft9 H4KSerine/threonine-protein kinase Chk1 2.7.11.1 0.726
3ac2 KSETyrosine-protein kinase Lck 2.7.10.2 0.697
2ym8 YM8Serine/threonine-protein kinase Chk1 2.7.11.1 0.689
4ft3 H1KSerine/threonine-protein kinase Chk1 2.7.11.1 0.688
2ydi YDISerine/threonine-protein kinase Chk1 2.7.11.1 0.687
4ft5 H2KSerine/threonine-protein kinase Chk1 2.7.11.1 0.684
4fic 0ULProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.683
3ac1 KZITyrosine-protein kinase Lck 2.7.10.2 0.682
4ft7 H3KSerine/threonine-protein kinase Chk1 2.7.11.1 0.672
4dt8 ADNAPH(2'')-Id / 0.667
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.665
4bdg P3JSerine/threonine-protein kinase Chk2 2.7.11.1 0.663
2e9v 85ASerine/threonine-protein kinase Chk1 2.7.11.1 0.662
2ym7 YM7Serine/threonine-protein kinase Chk1 2.7.11.1 0.662
2e9u A25Serine/threonine-protein kinase Chk1 2.7.11.1 0.659
3sd0 TSKGlycogen synthase kinase-3 beta 2.7.11.26 0.659
4hvh 19RTyrosine-protein kinase JAK3 2.7.10.2 0.659
4y3j HICEndothiapepsin 3.4.23.22 0.653
2oj9 BMIInsulin-like growth factor 1 receptor 2.7.10.1 0.651
2wmq ZYQSerine/threonine-protein kinase Chk1 2.7.11.1 0.651