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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f64 0S8 Fibroblast growth factor receptor 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4f64 0S8Fibroblast growth factor receptor 1 / 0.961
4nka 2K7Fibroblast growth factor receptor 1 / 0.799
4f65 0S9Fibroblast growth factor receptor 1 / 0.778
4nks 2M2Fibroblast growth factor receptor 1 / 0.772
4f63 0S7Fibroblast growth factor receptor 1 / 0.760
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.737
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.719
4jbq VX6Aurora kinase A 2.7.11.1 0.718
3ggf GVDSerine/threonine-protein kinase 26 / 0.712
4c61 LMMTyrosine-protein kinase JAK2 / 0.710
3w10 RO9Aurora kinase A 2.7.11.1 0.707
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.706
2xyn VX6Abelson tyrosine-protein kinase 2 2.7.10.2 0.701
3w16 P9JAurora kinase A 2.7.11.1 0.700
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.695
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.690
3i81 EBIInsulin-like growth factor 1 receptor 2.7.10.1 0.685
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.685
3vid 4TTVascular endothelial growth factor receptor 2 2.7.10.1 0.683
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.682
3nlb 5BESerine/threonine-protein kinase Chk1 2.7.11.1 0.681
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.680
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.675
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.674
1oec AA2Fibroblast growth factor receptor 2 / 0.672
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.668
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.664
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.664
2bkz SBCCyclin-dependent kinase 2 2.7.11.22 0.662
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.662
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.661
3zdu 38RCyclin-dependent kinase-like 3 2.7.11.22 0.661
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.661
3vf8 0JETyrosine-protein kinase SYK 2.7.10.2 0.660
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.659
4b8m VX6Aurora kinase B-A 2.7.11.1 0.659
5d12 G97Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.659
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.658
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.658
2c3k ABOSerine/threonine-protein kinase Chk1 2.7.11.1 0.655
2x4z X4ZSerine/threonine-protein kinase PAK 4 2.7.11.1 0.655
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.655
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.654
2wpa 889Cyclin-dependent kinase 2 2.7.11.22 0.652
4o0r X4ZSerine/threonine-protein kinase PAK 1 2.7.11.1 0.650