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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4f63 0S7 Fibroblast growth factor receptor 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4f63 0S7Fibroblast growth factor receptor 1 / 0.864
4f64 0S8Fibroblast growth factor receptor 1 / 0.760
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4nka 2K7Fibroblast growth factor receptor 1 / 0.727
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.716
4nks 2M2Fibroblast growth factor receptor 1 / 0.714
4jbq VX6Aurora kinase A 2.7.11.1 0.709
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.703
4f65 0S9Fibroblast growth factor receptor 1 / 0.702
4c61 LMMTyrosine-protein kinase JAK2 / 0.700
4o0r X4ZSerine/threonine-protein kinase PAK 1 2.7.11.1 0.700
3w16 P9JAurora kinase A 2.7.11.1 0.694
2x4z X4ZSerine/threonine-protein kinase PAK 4 2.7.11.1 0.689
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.684
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.683
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.681
3w10 RO9Aurora kinase A 2.7.11.1 0.681
2j4z 626Aurora kinase A 2.7.11.1 0.680
3e5a VX6Aurora kinase A 2.7.11.1 0.680
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.680
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.676
2xyn VX6Abelson tyrosine-protein kinase 2 2.7.10.2 0.676
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.676
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.676
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.675
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.674
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.674
2r64 740Cyclin-dependent kinase 2 2.7.11.22 0.673
3ggf GVDSerine/threonine-protein kinase 26 / 0.673
4nk9 2K5Fibroblast growth factor receptor 1 / 0.673
2bmc MPYAurora kinase A 2.7.11.1 0.667
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.666
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.664
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.664
3i81 EBIInsulin-like growth factor 1 receptor 2.7.10.1 0.663
4ag8 AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.663
4ks7 X4ZSerine/threonine-protein kinase PAK 6 2.7.11.1 0.663
4e5f 0N7Polymerase acidic protein / 0.660
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.657
1oec AA2Fibroblast growth factor receptor 2 / 0.656
4b8m VX6Aurora kinase B-A 2.7.11.1 0.656
1oiq HDUCyclin-dependent kinase 2 2.7.11.22 0.655
2j50 627Aurora kinase A 2.7.11.1 0.655
2f4j VX6Tyrosine-protein kinase ABL1 2.7.10.2 0.654
2jc6 QPPCalcium/calmodulin-dependent protein kinase type 1D 2.7.11.17 0.654
4aoj V4ZHigh affinity nerve growth factor receptor 2.7.10.1 0.653
1y6a AAZVascular endothelial growth factor receptor 2 2.7.10.1 0.652
4fst HK4Serine/threonine-protein kinase Chk1 2.7.11.1 0.652
2wpa 889Cyclin-dependent kinase 2 2.7.11.22 0.650
3nlb 5BESerine/threonine-protein kinase Chk1 2.7.11.1 0.650
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.650
4agc AXIVascular endothelial growth factor receptor 2 2.7.10.1 0.650
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.650