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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eok 4SP Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4eok 4SPCyclin-dependent kinase 2 2.7.11.22 0.890
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1ogu ST8Cyclin-dependent kinase 2 2.7.11.22 0.727
2iw8 4SPCyclin-dependent kinase 2 2.7.11.22 0.727
3rpy 27ZCyclin-dependent kinase 2 2.7.11.22 0.721
4eor 4SPCyclin-dependent kinase 2 2.7.11.22 0.718
1oiu N76Cyclin-dependent kinase 2 2.7.11.22 0.697
3o0g 3O0Cyclin-dependent-like kinase 5 2.7.11.1 0.692
1h1s 4SPCyclin-dependent kinase 2 2.7.11.22 0.688
3rk7 08ZCyclin-dependent kinase 2 2.7.11.22 0.687
2bts U32Cyclin-dependent kinase 2 2.7.11.22 0.686
2iw9 4SPCyclin-dependent kinase 2 2.7.11.22 0.682
2fvd LIACyclin-dependent kinase 2 2.7.11.22 0.676
3r9o Z71Cyclin-dependent kinase 2 2.7.11.22 0.674
2c6i DT1Cyclin-dependent kinase 2 2.7.11.22 0.671
1h1r 6CPCyclin-dependent kinase 2 2.7.11.22 0.670
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.668
4ez3 0S0Cyclin-dependent kinase 2 2.7.11.22 0.667
1oi9 N20Cyclin-dependent kinase 2 2.7.11.22 0.665
3rk5 07ZCyclin-dependent kinase 2 2.7.11.22 0.663
3s1h 56ZCyclin-dependent kinase 2 2.7.11.22 0.658
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.656
2uzd C85Cyclin-dependent kinase 2 2.7.11.22 0.652
1h1q 2A6Cyclin-dependent kinase 2 2.7.11.22 0.651