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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4egu 5GP Putative histidine triad (HIT) protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4egu 5GPPutative histidine triad (HIT) protein / 0.958
3n1s 5GPPurine nucleoside phosphoramidase / 0.894
3n1t 5GPPurine nucleoside phosphoramidase / 0.799
4eqg A5AHistidine triad nucleotide-binding protein 1 3 0.798
4eqe KAAHistidine triad nucleotide-binding protein 1 3 0.797
3oxk 5GPHistidine triad nucleotide-binding protein 3 0.795
5i2f BS5Histidine triad nucleotide-binding protein 1 3 0.789
1rzy 5ASHistidine triad nucleotide-binding protein 1 3 0.745
2h39 ADQADP-glucose phosphorylase / 0.713
3qgz ADNHistidine triad nucleotide-binding protein 1 3 0.700
5bv3 M7Gm7GpppX diphosphatase 3.6.1.59 0.697
1xmm M7Gm7GpppX diphosphatase 3.6.1.59 0.694
1st0 GTGm7GpppX diphosphatase 3.6.1.59 0.686
7mht SAHModification methylase HhaI 2.1.1.37 0.684
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.676
4xba GMPAprataxin-like protein 3 0.675
3a27 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.673
5fit AP2Bis(5'-adenosyl)-triphosphatase 3.6.1.29 0.672
3mht SAHModification methylase HhaI 2.1.1.37 0.669
1skm SAHModification methylase HhaI 2.1.1.37 0.664
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.663
4xba 5GPAprataxin-like protein 3 0.662
2ore SAHDNA adenine methylase 2.1.1.72 0.658
3q2k NAIProbable oxidoreductase / 0.658
2p35 SAHTrans-aconitate 2-methyltransferase / 0.655
3cbg SAHO-methyltransferase / 0.655
2rgh FADAlpha-Glycerophosphate Oxidase / 0.653
2uyh SAHModification methylase HhaI 2.1.1.37 0.650