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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e5o UMP Thymidylate synthase 2.1.1.45

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4e5o UMPThymidylate synthase 2.1.1.45 1.160
4eb4 UMPThymidylate synthase 2.1.1.45 1.112
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 1.069
4ein NOHThymidylate synthase 2.1.1.45 1.065
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 1.060
5by6 UMPThymidylate synthase / 1.047
4isk UMPThymidylate synthase / 1.002
1f28 UMPThymidylate synthase 2.1.1.45 0.990
4dq1 UMPThymidylate synthase / 0.980
2fto TMPThymidylate synthase / 0.947
4fox UMPThymidylate synthase ThyA / 0.936
1tys TMPThymidylate synthase / 0.923
3qj7 UMPThymidylate synthase ThyA / 0.912
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.902
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.880
1bid UMPThymidylate synthase / 0.857
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.856
4h0u UMPThymidylate synthase / 0.841
2tsr UMPThymidylate synthase 2.1.1.45 0.835
2vet UMPThymidylate synthase / 0.826
4iqq UMPThymidylate synthase / 0.826
4psg NOHThymidylate synthase / 0.818
1nja DCMThymidylate synthase / 0.816
2g86 UMPThymidylate synthase / 0.809
4irr UMPThymidylate synthase / 0.802
3bgx TMPThymidylate synthase / 0.800
1tsy UMPThymidylate synthase / 0.795
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.790
1jmf UMPThymidylate synthase / 0.790
1vzb UMPThymidylate synthase / 0.780
2g8a UMPThymidylate synthase / 0.775
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.775
1vza UMPThymidylate synthase / 0.773
1bp0 UMPThymidylate synthase / 0.772
1tsx UMPThymidylate synthase / 0.750
2tdm UMPThymidylate synthase / 0.747
1ddu DDUThymidylate synthase / 0.740
3lzx NAPFerredoxin--NADP reductase 2 1.18.1.2 0.737
1bp6 UMPThymidylate synthase / 0.735
1jmg UMPThymidylate synthase / 0.706
1jmh UMPThymidylate synthase / 0.705
2g89 UMPThymidylate synthase / 0.702
1bpj UMPThymidylate synthase / 0.701
1tsv UMPThymidylate synthase / 0.697
1tdc UMPThymidylate synthase / 0.695
3lzw NAPFerredoxin--NADP reductase 2 1.18.1.2 0.695
4gcm NAPThioredoxin reductase 1.8.1.9 0.691
1bdu DURThymidylate synthase / 0.687
1njd UMPThymidylate synthase / 0.683
2g8d UMPThymidylate synthase / 0.680
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.671
2wba NDPTrypanothione reductase 1.8.1.12 0.669
4xsd UMPThymidylate synthase 2.1.1.45 0.669
1nje DCMThymidylate synthase / 0.667
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.660
4cbq NDPThioredoxin reductase / 0.659
4hs4 FMNChromate reductase / 0.653
1aj2 2PHDihydropteroate synthase / 0.652
3koy Z97D-ornithine 4,5-aminomutase subunit beta / 0.652
4utl FNRXenobiotic reductase / 0.652
1g3l TRHGlucose-1-phosphate thymidylyltransferase / 0.651
1ytm ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.650
5f1c ATPUncharacterized protein / 0.650