Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dwb 0M7 Farnesyl pyrophosphate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dwb 0M7Farnesyl pyrophosphate synthase / 1.071
4dem YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.910
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.909
4lfv YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.905
4h5d YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.901
4kqs RISFarnesyl pyrophosphate synthase 2.5.1.10 0.898
4h5c YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.886
3rye UNRFarnesyl pyrophosphate synthase 2.5.1.10 0.869
4q23 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.865
3ez3 ZOLFarnesyl pyrophosphate synthase, putative / 0.861
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.859
4dxj 0M9Farnesyl pyrophosphate synthase / 0.844
4nke RISFarnesyl pyrophosphate synthase 2.5.1.10 0.839
4ga3 4GAFarnesyl pyrophosphate synthase 2.5.1.10 0.836
3icz PB6Farnesyl pyrophosphate synthase / 0.835
4l2x YL2Farnesyl pyrophosphate synthase 2.5.1.10 0.812
1yv5 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.809
3ldw ZOLFarnesyl pyrophosphate synthase, putative / 0.806
3krf DSTGeranyl diphosphate synthase large subunit / 0.799
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.775
2zev B71Geranylgeranyl pyrophosphate synthase / 0.756
3oab DSTGeranyl diphosphate synthase large subunit / 0.741
1yq7 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.739
2o1o RISPutative farnesyl pyrophosphate synthase / 0.725
2z4w 749Geranylgeranyl pyrophosphate synthase / 0.725
2z52 H23Geranylgeranyl pyrophosphate synthase / 0.724
2f94 BFQFarnesyl pyrophosphate synthase 2.5.1.10 0.718
1khe GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.716
5erm 210Fusicoccadiene synthase 4.2.3.43 0.713
3egt 722Farnesyl pyrophosphate synthase / 0.711
2i19 1BYFarnesyl pyrophosphate synthase / 0.706
3m0e ATPTranscriptional regulator (NtrC family) / 0.705
4hut ATPCob(I)yrinic acid a,c-diamide adenosyltransferase 2.5.1.17 0.700
4qfy DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.700
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
3n0z 3ATAdenylate cyclase 2 / 0.687
1oe0 TTPDeoxynucleoside kinase / 0.686
2e93 B29Geranylgeranyl pyrophosphate synthase / 0.685
4mrt COA4'-phosphopantetheinyl transferase sfp 2.7.8 0.682
4yj2 GTPTubulin alpha-1B chain / 0.682
4b1v ATPActin, alpha skeletal muscle / 0.680
2cvx DGTRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.679
2opm NI9Farnesyl pyrophosphate synthase 2.5.1.10 0.679
3ryw K9HFarnesyl pyrophosphate synthase, putative / 0.679
1p52 ADPArginine kinase 2.7.3.3 0.678
2e8w IPEGeranylgeranyl pyrophosphate synthase / 0.678
1kxp ATPActin, alpha skeletal muscle / 0.677
3ryh GTPTubulin alpha chain / 0.677
3w2w ATPCRISPR system Cmr subunit Cmr2 / 0.675
1os1 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.674
1peq TTPRibonucleoside-diphosphate reductase 2 subunit alpha 1.17.4.1 0.674
1dej ATPMajor actin / 0.673
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.672
5itz GTPTubulin alpha-1B chain / 0.668
4iij GTPTubulin alpha-1B chain / 0.667
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.666
1mb9 ATPCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.666
2q36 ATPActin, alpha skeletal muscle / 0.666
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.666
4tv9 GTPTubulin alpha-1B chain / 0.666
3ump ATPATP-dependent 6-phosphofructokinase isozyme 2 2.7.1.11 0.665
3zcb ATPAdenosine monophosphate-protein transferase VbhT 2.7.7.n1 0.665
2qtc TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.664
3tb9 ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.664
4pki ATPActin, alpha skeletal muscle / 0.664
3ai3 NDPNADPH-sorbose reductase / 0.663
3lzx NAPFerredoxin--NADP reductase 2 1.18.1.2 0.663
4pkg ATPActin, alpha skeletal muscle / 0.663
5ero 210Fusicoccadiene synthase 2.5.1.29 0.663
1s22 ATPActin, alpha skeletal muscle / 0.662
1x09 IPEDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) 2.5.1.31 0.662
3dt2 GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.662
4k41 ATPActin, alpha skeletal muscle / 0.662
1ja1 NAPNADPH--cytochrome P450 reductase / 0.661
1t44 ATPActin, alpha skeletal muscle / 0.661
3b05 IPEIsopentenyl-diphosphate delta-isomerase / 0.661
3dt4 GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.661
1xje TTPVitamin B12-dependent ribonucleotide reductase / 0.660
2jiz ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.660
3dyh 721Farnesyl pyrophosphate synthase / 0.660
3l8y GNPGTPase HRas / 0.659
3mvy BHZNickel-binding periplasmic protein / 0.657
1e1m NAPNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.656
1t8x PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.656
2rgg GNPGTPase HRas / 0.656
3ar4 ATPSarcoplasmic/endoplasmic reticulum calcium ATPase 1 3.6.3.8 0.656
3tgp GNPGTPase HRas / 0.656
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.655
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.655
1wua ATPActin, alpha skeletal muscle / 0.655
4dbz NDPPutative ketoacyl reductase 1.3.1 0.655
1khb GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.654
2v6g NAP3-oxo-Delta(4,5)-steroid 5-beta-reductase / 0.654
3k9l GNPGTPase HRas / 0.654
3n0y APCAdenylate cyclase 2 / 0.653
4gvz ADPArginine kinase 2.7.3.3 0.653
1pno NAPNAD(P) transhydrogenase subunit beta 1.6.1.2 0.652
2y6p CTP3-deoxy-manno-octulosonate cytidylyltransferase 2.7.7.38 0.652
3ojx NAPNADPH--cytochrome P450 reductase / 0.652
3qbt GNPRas-related protein Rab-8A / 0.652
3sx2 NADUncharacterized protein / 0.652
3tso GNPRas-related protein Rab-25 / 0.651
5la6 GTPTubulin alpha-1B chain / 0.651
3rbm B73Farnesyl pyrophosphate synthase, putative / 0.650
4tuy GTPTubulin alpha-1B chain / 0.650
4wbn GTPTubulin alpha-1B chain / 0.650
5jqg GTPTubulin alpha-1B chain / 0.650