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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ddr MMV Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ddr MMVDihydrofolate reductase 1.5.1.3 1.112
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3qg2 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.741
3um5 CP6Bifunctional dihydrofolate reductase-thymidylate synthase / 0.739
1j3j CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.725
3gyf 51PDihydrofolate reductase 1.5.1.3 0.710
3inv C50Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.703
2blb CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.694
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.688
2blc CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.678
4m2x TMQDihydrofolate reductase 1.5.1.3 0.675
3nxo D2BDihydrofolate reductase 1.5.1.3 0.662
4e5f 0N7Polymerase acidic protein / 0.660
1hfp MOTDihydrofolate reductase 1.5.1.3 0.659
1hfr MOTDihydrofolate reductase 1.5.1.3 0.658
3i8a N22Dihydrofolate reductase 1.5.1.3 0.657
4kd7 9DRDihydrofolate reductase 1.5.1.3 0.654
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.653
4qi9 MTXDihydrofolate reductase / 0.653
4kak 06UDihydrofolate reductase 1.5.1.3 0.651