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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ccu AWF ALK tyrosine kinase receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ccu AWFALK tyrosine kinase receptor 2.7.10.1 1.026
4cd0 AWJALK tyrosine kinase receptor 2.7.10.1 0.978
4ccb OFGALK tyrosine kinase receptor 2.7.10.1 0.926
4ans VGHALK tyrosine kinase receptor 2.7.10.1 0.794
2yfx VGHALK tyrosine kinase receptor 2.7.10.1 0.769
5aac VGHALK tyrosine kinase receptor 2.7.10.1 0.747
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
5aab VGHALK tyrosine kinase receptor 2.7.10.1 0.737
4anq VGHALK tyrosine kinase receptor 2.7.10.1 0.680
2xp2 VGHALK tyrosine kinase receptor 2.7.10.1 0.675
3qtu X44Cyclin-dependent kinase 2 2.7.11.22 0.675
3rpv 26ZCyclin-dependent kinase 2 2.7.11.22 0.669
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.665
4e5f 0N7Polymerase acidic protein / 0.660
5aaa VGHALK tyrosine kinase receptor 2.7.10.1 0.660
3rk5 07ZCyclin-dependent kinase 2 2.7.11.22 0.658
3r8z Z63Cyclin-dependent kinase 2 2.7.11.22 0.656
4e4l 0NHTyrosine-protein kinase JAK1 / 0.655
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.651
3rk7 08ZCyclin-dependent kinase 2 2.7.11.22 0.650