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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4brx KGW Focal adhesion kinase 1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4brx KGWFocal adhesion kinase 1 2.7.10.2 1.040
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.986
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.763
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.752
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.732
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.729
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.702
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.692
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.691
4bcq TJFCyclin-dependent kinase 2 2.7.11.22 0.679
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.675
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.675
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.669
4jia 1K3Tyrosine-protein kinase JAK2 / 0.669
1oi9 N20Cyclin-dependent kinase 2 2.7.11.22 0.658
2x1n X1NCyclin-dependent kinase 2 2.7.11.22 0.656
3v5l 0G1Tyrosine-protein kinase ITK/TSK 2.7.10.2 0.656
1m2r MNYCasein kinase II subunit alpha 2.7.11.1 0.650
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.650