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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4biw ANP Sensor histidine kinase CpxA

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4biw ANPSensor histidine kinase CpxA / 1.120
3sl2 ATPSensor histidine kinase WalK / 0.842
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.743
2c2a ADPSensor histidine kinase / 0.741
4jau ADPSensor histidine kinase / 0.712
4wud ANPDNA gyrase subunit B / 0.708
4pl9 ADPEthylene receptor 1 / 0.705
1nhh ANPDNA mismatch repair protein MutL / 0.703
4bix ADPSensor histidine kinase CpxA / 0.694
4wuc ANPDNA gyrase subunit B / 0.689
3t0z ATPHeat shock protein HSP 90-alpha / 0.688
1til ATPAnti-sigma F factor / 0.685
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.679
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.678
4xfj ANPArgininosuccinate synthase / 0.676
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.671
2bu2 ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.670
1s16 ANPDNA topoisomerase 4 subunit B / 0.666
2yef ANPHeat shock protein HSP 90-alpha / 0.658
2zdy ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.655
3t1k ANPHeat shock protein HSP 90-alpha / 0.654