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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bbf O19 Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bbf O19Tyrosine-protein kinase JAK2 / 0.998
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.767
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2x81 ZZLAurora kinase A 2.7.11.1 0.726
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.726
3lpb NVBTyrosine-protein kinase JAK2 / 0.721
4dea NHIAurora kinase A 2.7.11.1 0.710
4im2 BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.708
1y57 MPZProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.705
4aqc 88ATyrosine-protein kinase JAK2 / 0.705
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.691
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.686
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.683
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.671
1pxl CK4Cyclin-dependent kinase 2 2.7.11.22 0.663
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.663
4grb 0XGCasein kinase II subunit alpha 2.7.11.1 0.663
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.660
3o0g 3O0Cyclin-dependent-like kinase 5 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4jia 1K3Tyrosine-protein kinase JAK2 / 0.659
2rku R78Serine/threonine-protein kinase PLK1 2.7.11.21 0.656
3i4b Z48Glycogen synthase kinase-3 beta 2.7.11.26 0.656
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.654
5dt0 SKEAurora kinase A 2.7.11.1 0.654
1m52 P17Tyrosine-protein kinase ABL1 2.7.10.2 0.652
5dr6 SKEAurora kinase A 2.7.11.1 0.650