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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b00 I6X Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4b00 I6XBeta-secretase 1 3.4.23.46 0.910
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4b1d 6TGBeta-secretase 1 3.4.23.46 0.720
4b1c 1B1Beta-secretase 1 3.4.23.46 0.712
4b05 32DBeta-secretase 1 3.4.23.46 0.694
4azy 7F3Beta-secretase 1 3.4.23.46 0.682
4acx S8ZBeta-secretase 1 3.4.23.46 0.674
4b0q GMFBeta-secretase 1 3.4.23.46 0.672
4frs 0V6Beta-secretase 1 3.4.23.46 0.668
4e5f 0N7Polymerase acidic protein / 0.660
4acu QN7Beta-secretase 1 3.4.23.46 0.658
4djv 0KMBeta-secretase 1 3.4.23.46 0.658