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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4aoj V4Z High affinity nerve growth factor receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4aoj V4ZHigh affinity nerve growth factor receptor 2.7.10.1 1.034
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2xba 571ALK tyrosine kinase receptor 2.7.10.1 0.728
4f65 0S9Fibroblast growth factor receptor 1 / 0.705
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.699
3zmm F9JTyrosine-protein kinase JAK2 / 0.690
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.683
3ggf GVDSerine/threonine-protein kinase 26 / 0.674
4c61 LMMTyrosine-protein kinase JAK2 / 0.674
2ghl LIBMitogen-activated protein kinase 14 / 0.668
2x2l X2LProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.666
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.664
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.663
4e5f 0N7Polymerase acidic protein / 0.660
2v7a 627Tyrosine-protein kinase ABL1 2.7.10.2 0.656
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.655
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
4f63 0S7Fibroblast growth factor receptor 1 / 0.653
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.651
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.650